Survival of nerve and Schwann cells in allografts after cyclosporin A treatment |
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| Authors: | A A Zalewski A K Gulati |
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| Institution: | Laboratory of Neurochemistry, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205 USA |
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| Abstract: | Because nerve and Schwann cells in allografts are rejected by normal rats, we investigated whether or not these neurological cells would survive if rats were treated with the new immunosuppressive drug, Cyclosporin A. Untreated rats rejected nerve and Schwann cells in allografts of ganglia or nerve. On the other hand, nerve and Schwann cells survived in allografts in Cyclosporin A-treated rats even after drug therapy was terminated. These results indicate that Cyclosporin A may be of value if allogenic nerve or Schwann cells are needed to aid in the repair of injured nerve tissue. |
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| Keywords: | CsA Cyclosporin A LE Lewis BN Brown Norway TA tibialis anterior EDL extensor digitorum longus PAS hematoxylin—periodic acid-Schiff-hematoxylin |
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