乙型肝炎表面抗原无症状携带者的传染性及其传染源作用的研究

通过对无症状HBsAg携带者血清的HBeAg、HBV-DNA和Dane颗粒检查,揭示HBeAg、HBV-DNA均为阳性HBsAg的无症状携带者的血清具有传染性,而单纯HBsAg阳性(HBeAg、HBV-DNA均为阴性)血清传染性不强。
经三年观察,发现HBsAg、HBeAg、HBV-DNA均阳性的无症状携带者对同一个班内密切接触者能引起HBV感染,其感染的相对危险性比对照组高3.7倍。

A study on the Infectivity of Asymptomatic HBsAg Carrier and Its Role in the Trnsmission of Hepatitis B Virus

Sera from 126 HBsAg carriers of asymptomatic were tested for the pesence of HBsAg (ELI SA), hepatitis B virus (HBV) DNA (fed molecular hybridization test) and Dane particles (IEM). The results showed that HBeAg-postive carriers were 51 cases (40.48%). Of the 51 serum samples positive rates for HBV-DNA and dane particles were found to be 100%. Carriers whose serum specimens contained HBeAg HBV-DNA and Dane particles were concidered with in fectivity. To study the role of asymptomatic HBsAg carriers as transmitter. A follow-up study to compare the infection rates of HBeAg, HBV DNA, Dane Particles positive group and healthy control group was carried out. After two years of exposure, the results showed that sera of asymptomatic HBsAg carriers played an important role in the transmission of hepatitis B virus.