Bone mineral density of the lumbar spine in very-low-birth-weight infants: a longitudinal study |
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Authors: | H Ichiba H Shintaku M Fujimaru C Hirai Y Okano M Funato |
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Institution: | (1) Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP;(2) Department of Pediatrics, Yodogawa Christian Hospital, Osaka, Japan, JP |
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Abstract: | To examine osteopenia in very low birth weight (VLBW) infants we used repeated dual-energy X-ray absorptiometry in a prospective
study of lumbar spinal bone mineral density (BMD) in Japanese VLBW infants (birthweight 426–1498 g; n = 61, group 1) aged 40 weeks postconception to 3 years of age. Control subjects were Japanese infants with birthweight 1500–1999 g
(group 2), 2000–2499 g (group 3), or more than 2500 g (group 4). BMD in group 1 during the early period after birth was very
low, increased rapidly for 1 year, and then gradually increased until 3 years of age (r = 0.931, P < 0.0001). BMD at the age of 40 weeks postconception was 0.085 ± 0.026, 0.132 ± 0.039, 0.178 ± 0.042, and 0.196 ± 0.046 g/cm2 in groups 1, 2, 3, and 4, respectively (P < 0.0001). However, at 1 and 2 years of age no differences were observed among the groups in BMD.
Conclusion This study shows that lumbar spinal BMD in VLBW infants can normalize by the age of 2 years.
Received: 12 May 1999 / Accepted: 11 October 1999 |
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Keywords: | Very-low-birth-weight infant Bone mineral density Dual energy X-ray absorptiometry Osteopenia |
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