Induction of prostate specific antigen production by steroids and tamoxifen in breast cancer cell lines |
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| Authors: | He Yu Eleftherios P. Diamandis Nosratollah Zarghami Linda Grass |
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| Affiliation: | (1) Department of Clinical Biochemistry, Toronto Western Division, The Toronto Hospital, 399 Bathurst Street, M5T 2S8 Toronto, Ontario, Canada;(2) Department of Clinical Biochemistry, University of Toronto, 100 College Street, M5G 1L5 Toronto, Ontario, Canada |
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| Abstract: | Summary We demonstrate that the steroid hormone receptor-positive breast carcinoma cell lines T-47D and MCF-7 can be induced by androgens, progestins, mineralocorticosteroids, glucocorticosteroids, and antiestrogens, to produce prostate specific antigen (PSA). Estrogens failed to induce such stimulation in both cell lines and, in addition, were able to block the induction by androgens in the cell line T-47D. These data support and extend our previous report on PSA production by breast tumors and describe anin vitro system which can be used to study the phenomenon for possible application in prognosis and design of new therapy. |
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| Keywords: | breast cancer cell lines breast cancer prognosis prostate specific antigen PSA gene regulation PSA in breast cancer steroid hormone receptors |
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