Tissue distribution and excretion of hexabromobenzene and its debrominated metabolites in the rat |
| |
Authors: | Yukihiko Yamaguchi Masahide Kawano Ryo Tatsukawa |
| |
Institution: | (1) Department of Environment Conservation, Ehime University, Tarumi 3-5-7, 790 Matsuyama, Japan |
| |
Abstract: | Tissue distribution and excretion of hexabromobenzene (HBB) and some metabolites were studied in male Wistar rats administered a single oral dosage of HBB.Most of the HBB dosage was absorbed by the intestinal tract and it was rapidly metabolized and distributed throughout the body as the debrominated metabolites, pentabromobenzene (PeBB), tetrabromobenzene (TeBB) and tribromobenzene (TrBB). The time courses of HBB, PeBB and TeBB concentrations in the tissues were roughly classified into several types, and debromination of HBB was found to take place stepwise.The reductive debromination of HBB occurs by metabolic enzymes in the liver rather than microbes in the intestine. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|