影响中晚期卵巢上皮癌预后的治疗因素分析

目的：探讨综合治疗因素对中晚期上皮性卵巢癌预后的影响,方法：分析1990－1997年治疗的91例中晚期卵巢癌的手术范围,术后残余病灶大小,术后化疗疗程数及化疗途径,并随访预后,用Log-Rank检验和Cox模型作生存分析。结果：全组3年和5年生存活率分别为39．21％和36．89％,经单因素分析,与预后有关的因素是术后残余病灶大小,化疗疗九,临床分期及组织学分级,经Cox模型多因素分析,影响预后的独立因子是临床分期和组织学分级,结论：手术范围和化疗途径与上皮性卵巢癌预后无关,手术达理想的肿瘤细胞减灭术及顺铂联合化疗≥6疗程者可获较长期生存,临床分期及组织学分级仍是影响卵巢上皮性癌预后的主要因素。

Therapeutic factors analysis in prognosis of middle-advanced epithelial ovarian carcinoma

Objective To study the effect of therapeutic factors on the prognosis of middle-advanced epithelial ovarian carcinoma.Methods Operative range?residual cancer focus after surgery?times of chemotherapy?chemotherapeutic ways of 91 resident patients with middle-advanced epithelial ovarian carcinoma were analyzed retrospectively and the prognosis was investigated by following up.The univariate Log Rank test and multivariates Cox model were used in data analysis.Results The overall 3-and 5-year survival rates were 39 21%and 26 89%,respectively.In univariate analysis of Log Rank test,the factors related to prognosis of ovarian carcinoma were residual cancer focus after surgery,times of chemotherapy,clinical stage and histological grade.In multivariates analysis of Cox model,clinical stage and histological grade were independent factors that affected the prognosis of ovarian carcinoma.Conclusion Operative range and chemotherapeutic ways are not related to the prognosis of ovarian carcinoma.Optimal cytoreductive surgery and more than 6 times of cisplatin combination chemotherpy may be benefitial to the patients with middle-advanced epithelial ovarian carcinoma.Clinical stage and histological grade are still the important prognostic factors in the epithelial ovarian cancer.