| 自然流产、无精症和先天愚型患者外周血染色体核型分析 |
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| 引用本文： | 辛暨丽,刘睿智,李哲,刘丽萍,王忠山. 自然流产、无精症和先天愚型患者外周血染色体核型分析[J]. 吉林大学学报(医学版), 2003, 29(5): 570-572 |
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| 作者姓名： | 辛暨丽 刘睿智 李哲 刘丽萍 王忠山 |
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| 作者单位： | 1. 吉林大学基础医学院细胞生物学教研室,吉林,长春,130021
2. 吉林省妇幼保健院 |
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| 基金项目： | 吉林省计委资助项目;1999; |
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| 摘 要： | 目的 :阐述自然流产、男性无精子症、先天愚型以及其它病症 (畸形、肥胖等 )与染色体变异的关系 ,以便做出及时、准确诊断。方法 :人外周血淋巴细胞染色体 G显带的检测。结果 :受检5 94例中染色体异常 5 8例 (异常率 9.73% )。其中自然流产患者 2 62例 ,异常 1 8例 (异常率6.87% ) ;无精子症 2 1 5例 ,异常 2 6例 (异常率 1 2 .0 9% ) ;先天愚型 32例 ,异常 1 2例 (异常率37.5 % ) ;其它病症 (畸形、肥胖等 ) 85例 ,异常 2例 (异常率 2 .35 % )。结论 :染色体核型分析有助于自然流产、男性无精症和先天愚型的病因诊断
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| 关 键 词： | 流产,自然/遗传学 少精子症/遗传学 唐氏综合征/遗传学 染色体,人/遗传学 核型分析 |
| 文章编号： | 1671-587X(2003)05-0570-03 |
| 修稿时间： | 2002-08-05 |
Analysis of Chromosomal Karyotypes of Peripheral Blood Lymphocytes in Patients with Spoutanous Abortion, Azoospermia and Down Syndrome |
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| XIN Ji li ,LIU Rui zhi ,LI Zhe ,LIU Li ping ,WANG Zhong shan. Analysis of Chromosomal Karyotypes of Peripheral Blood Lymphocytes in Patients with Spoutanous Abortion, Azoospermia and Down Syndrome[J]. Journal of Jilin University: Med Ed, 2003, 29(5): 570-572 |
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| Authors: | XIN Ji li LIU Rui zhi LI Zhe LIU Li ping WANG Zhong shan |
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| Affiliation: | XIN Ji li 1,LIU Rui zhi 1,LI Zhe 1,LIU Li ping 2,WANG Zhong shan 1 |
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| Abstract: | Obective:To study on the relationship between spontaneous abortion, Azoospermia, Down syndrome or other illness ( lopsided, fat etc.) and chromosome variation, in order to make accurate diagnosis. Methods: Chromosome of peripheral blood lymphocytes were performed to analysis the abnormal karyotypes in 594 patients. Results:Chromosome abnormal rate was 9.73% in 594 patients.In 262 spontaneous abortion patients, chromosome abnormal rate was 6.87%. In 215 Azoospermia, chromosome abnormal rate was 12.09%. In 32 Down symptom, chromosome abnormal rate was 37.5%. In 85 other illness (lopsided, fat etc.) patients, chromosome abnormal rate was 2.35%. Conclusion: Chromosome analysis technique has important application in cytogenesis etiology. [ |
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| Keywords: | Abortion spontaneous/genetils Oligspermia/genetics Down syndrome/genetics Chromosome human/genetics Karyotype analysis |
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