| 自然流产、无精症和先天愚型患者外周血染色体核型分析 |
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| 引用本文： | 辛暨丽,刘睿智,李哲,刘丽萍,王忠山.自然流产、无精症和先天愚型患者外周血染色体核型分析[J].吉林大学学报(医学版),2003,29(5):570-572. |
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| 作者姓名： | 辛暨丽 刘睿智 李哲 刘丽萍 王忠山 |
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| 作者单位： | 1. 吉林大学基础医学院细胞生物学教研室,吉林,长春,130021
2. 吉林省妇幼保健院 |
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| 基金项目： | 吉林省计委资助项目;1999; |
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| 摘 要： | 目的 :阐述自然流产、男性无精子症、先天愚型以及其它病症 (畸形、肥胖等 )与染色体变异的关系 ,以便做出及时、准确诊断。方法 :人外周血淋巴细胞染色体 G显带的检测。结果 :受检5 94例中染色体异常 5 8例 (异常率 9.73% )。其中自然流产患者 2 62例 ,异常 1 8例 (异常率6.87% ) ;无精子症 2 1 5例 ,异常 2 6例 (异常率 1 2 .0 9% ) ;先天愚型 32例 ,异常 1 2例 (异常率37.5 % ) ;其它病症 (畸形、肥胖等 ) 85例 ,异常 2例 (异常率 2 .35 % )。结论 :染色体核型分析有助于自然流产、男性无精症和先天愚型的病因诊断
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| 关 键 词： | 流产 自然/遗传学 少精子症/遗传学 唐氏综合征/遗传学 染色体 人/遗传学 核型分析 |
| 文章编号： | 1671-587X(2003)05-0570-03 |
| 修稿时间： | 2002年8月5日 |
Analysis of Chromosomal Karyotypes of Peripheral Blood Lymphocytes in Patients with Spoutanous Abortion, Azoospermia and Down Syndrome |
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| XIN Ji li ,LIU Rui zhi ,LI Zhe ,LIU Li ping ,WANG Zhong shan.Analysis of Chromosomal Karyotypes of Peripheral Blood Lymphocytes in Patients with Spoutanous Abortion, Azoospermia and Down Syndrome[J].Journal of Jilin University: Med Ed,2003,29(5):570-572. |
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| Authors: | XIN Ji li LIU Rui zhi LI Zhe LIU Li ping WANG Zhong shan |
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| Institution: | XIN Ji li 1,LIU Rui zhi 1,LI Zhe 1,LIU Li ping 2,WANG Zhong shan 1 |
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| Abstract: | Obective:To study on the relationship between spontaneous abortion, Azoospermia, Down syndrome or other illness ( lopsided, fat etc.) and chromosome variation, in order to make accurate diagnosis. Methods: Chromosome of peripheral blood lymphocytes were performed to analysis the abnormal karyotypes in 594 patients. Results:Chromosome abnormal rate was 9.73% in 594 patients.In 262 spontaneous abortion patients, chromosome abnormal rate was 6.87%. In 215 Azoospermia, chromosome abnormal rate was 12.09%. In 32 Down symptom, chromosome abnormal rate was 37.5%. In 85 other illness (lopsided, fat etc.) patients, chromosome abnormal rate was 2.35%. Conclusion: Chromosome analysis technique has important application in cytogenesis etiology. |
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| Keywords: | Abortion spontaneous/genetils Oligspermia/genetics Down syndrome/genetics Chromosome human/genetics Karyotype analysis |
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