Prophylactic antiemetic effect of dexamethasone in women undergoing ambulatory laparoscopic surgery |
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Authors: | Wang J J Ho S T Liu H S Ho C M |
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Institution: | Department of Anesthesiology, Tri-Service General Hospital, Taipei, Taiwan. |
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Abstract: | The aim of this study was to evaluate the prophylactic antiemetic effect of
i.v. dexamethasone in women undergoing ambulatory laparoscopic tubal
ligation. Ninety patients requiring general anaesthesia for laparoscopic
tubal ligation were enrolled in a randomized, double-blind,
placebo-controlled study. Forty-five patients received dexamethasone 10 mg
i.v. and 45 received saline 2 ml i.v. at the induction of anaesthesia. We
found that 27% of patients in the dexamethasone group, compared with 63% of
patients in the saline group, reported nausea and vomiting within 4 h after
surgery (P < 0.01). Seven per cent of patients in the dexamethasone
group, compared with 28% of patients in the saline group, received a rescue
antiemetic (P < 0.05). During the 24-h postoperative observation period,
34% of patients in the dexamethasone group, compared with 73% of patients
in the saline group, reported nausea and vomiting (P < 0.001). We
conclude that dexamethasone 10 mg significantly decreases the incidence of
postoperative nausea and vomiting in women undergoing ambulatory
laparoscopic tubal ligation.
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