非定常流动情况下Womersley数和Reynolds数对腹主动脉瘤流动的影响

目的讨论非定常流动情况下，各参数对管壁压力和壁面切应力的影响，进而分析血液流动对内皮细胞和血管弹性的影响。方法应用两维对称模型模拟腹主动脉瘤中的非定常流动。结果Womersley数和Reynolds数越大，流动状态越复杂，涡的强度越大，对壁面切应力和压力都有很大的影响。结论壁面切应力和压力长期且快速的改变对内皮细胞和血管的强度产生影响，进而影响到动脉瘤的形成、成长和破裂。

THE EFFECTS OF WOMERSLEY NUMBER AND REYNOLDS NUMBER ON THE UNSTEADY FLOW OF ABDOMINAL AORTIC ANEURYSM

Objective The effects of Womersley number and Reynolds on the wall shear stress and wall pressure are discussed. Then the effects of flow patterns on the endothelium and the elasticity of the vascular wall are analyzed. Methods Two-dimensional symmetrical models are used to simulate the unsteady flow in the AAA models. Results Mean Reynolds number and Womersley number that affect the flow pattern and wall shear stress and wall pressure in the aneurysm are dealt with. The mean Reynolds number and Womersley number increase the strength of the vortex in the AAA. Conclusion This rapid oscillating nature of the shear stresses and wall pressure over a long period of time may be directly correlated with endothelial biology and atherogenesis and could have some weakening effects on the strength of the artery wall. These should have facilitated the initiation, growth and rupture of the aneurysm to some extent.