Sodium and potassium channels in epithelial cells from thymus glands and thymomas of myasthenia gravis patients |
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| Authors: | A. Marx J. Siara R. Rüdel |
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| Affiliation: | (1) Pathologisches Institut der Universität Würzburg, Josef-Schneider-Strasse 2, Würzburg, Federal Republic of Germany;(2) Abteilung für Allgemeine Physiologie der Universität Ulm, Albert-Einstein-Allee 11, W-7900 Ulm, Federal Republic of Germany |
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| Abstract: | In both normal and neoplastic epithelial cells from human thymus glands and thymomas, respectively, we found voltage-gated sodium and potassium channels that resemble the adult-type Na channel and the delayed outward rectifier K channel, respectively, of human skeletal muscle and mammalian nervous system. These voltage-gated ion channels might be part of a communication system between epithelial cells and other components of the microenvironment of the thymus. |
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| Keywords: | Ion channels Human thymus and thymoma Epithelial cells Whole-cell recording Myasthenia gravis |
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