哮喘儿童免疫球蛋白、补体及外周血嗜酸粒细胞水平变化的意义

目的 探讨哮喘患儿免疫球蛋白IgG、IgM、IgA、补体C_3、C_4和外周血嗜酸粒细胞(PBEC)的含量变化及临床意义。方法 采用免疫透射比浊法测定IgG、IgM、IgA、C_3、C_4,常规外周血嗜酸细胞计数。结果 哮喘发作期、缓解期患儿及对照儿童3者的IgG、IgM、IgA、C_3、C_4的含量间差别有显著性意义(P<0.0001);其中发作期与缓解期患儿的上述各指标间的差别无显著性意义(均P>O.05),而发作期患儿与对照儿童间差别有显著性意义(P<0.01)。三者嗜酸粒细胞数间差别亦有显著性意义(P<0.05)。结论 免疫球蛋白IgG、IgM、IgA、补体C_3、C_4在哮喘发作期含量降低,是哮喘气道炎症的重要参与因素,PBEC随哮喘缓解而降低,可作为观察病情变化的指标之一。

The significance of the change of immune globulin,complement and blood arounding eosinophile in asthma children

Objective To explore the change and clinical purpose of asthma chidren's immune globulin IgG, IgM, IgA, Complement C3, C4 and eosinophile. Methods To test IgG, IgM, IgA, C3 , C4 and normal blood around ing eoscno-phile's number by method of Immunonephelomyfry. Results There were significant differences in IgG, IgM, Iga, C3 and C4 amony the 3 groups ( P <0. 0001) , there were no difference between attack group and remittent group ( P >0.05), but there were differences between attack group and contrast groups ( P <0. 01). There were differences in eosinophile amony 3 groups ( P <0. 05). Conclusion The Immune globulin IgC, IgM, IgA and complement C3, C4's decrease for children with asthma in stage of attack are an important element of asthma tract inflammation. PBEC's decrease can be regarded as one of the reference to observe the change of stage of illness.