高位硬膜外阻滞治疗不稳定型心绞痛的初步研究

目的 :探讨高位硬膜外阻滞对不稳定型心绞痛 (UAP)的疗效 ,并观察血管紧张素Ⅱ在治疗前后的变化。方法 :5 0例不适宜做介入治疗的UAP病人 ,随机分为硬外阻滞组 (TEA组 )和对照组 ,并观察治疗前后心率、血压、心绞痛发作次数、时间、心电改变及血管紧张素Ⅱ (AgⅡ )水平。结果 :治疗后TEA组心绞痛缓解率 10 0 % ,心绞痛发作次数及时间均有改善。同时TEA组AgⅡ水平明显下降 ,较对照组有显著差异。结论 :TEA治疗UAP能显著止痛 ,改善心肌缺血状态 ,AgⅡ水平显著下降 ,具有有效、简便、安全等特点 ,是治疗UAP的一条途径

Preliminary study of thoracic epidural anesthesia in patients with unstable angina pectoris

Objective: To explore the clinical effect of thoracic epidural anesthesia (TEA) on patients with unstable angina pectoris (UAP) and observe the change of angiotension Ⅱ before and after the treatment.Methods: 50 patients who could not be treated by surgical intervention were randomized into two groups: a TEA group (n=25) and the control group (n=25). Heart rate, blood pressure, chest_pain attack, ECG change and the plasma of AgⅡ were measured througout the study.Results: The rate of patients chest_pain relief is 100% after TEA and the times and the intervals of angina pectoris attack were improved. Meanwhile, the plasma of AgⅡ decreased significantly compared with the control group. Conclusion: The patients with UAP treated with the TEA _ a new therapy _ can have chest_pain relieved the condition of myocardial ischemia improved and the level of AgⅡ decneased. So it is effective,simple and safe, to tareat UAP.