枳椇子对非酒精性脂肪肝大鼠肝脏病理损伤的防治作用

目的]探讨枳椇子对高脂饮食诱发的非酒精性脂肪肝(NAFLD)大鼠肝组织病理损伤的防治作用。方法]54只SD雄性大鼠随机分为5组,空白组普通饲料加蒸馏水灌胃,每天1次,其余组均高脂饲料喂养,其中模型组蒸馏水灌胃,易善复组和枳椇子高、低剂量组予相应药物和剂量灌胃,每天1次。90 d后分别观察各组的肝指数及肝组织学改变。结果]模型组大鼠的肝指数明显高于空白组(P0.01),肝组织广泛脂肪变,呈中、重度炎症。与模型组比较,高剂量枳椇子组能显著降低大鼠肝指数,并明显改善肝组织炎症程度;易善复组肝指数略低于高剂量枳椇子组,肝组织学无明显改变。结论]早期、足量地用枳椇子干预对高脂饮食引起的大鼠NAFLD有效。

Prevention effect of Zhijuzi on liver pathological injury in rats with non-alcoholic fatty liver

Objective]To explore the effect of Zhijuzi on liver pathology of high-fat diet-induced non-alcoholic fatty liver.Methods]Fifty-four male SD rats were randomly divided into 5 groups,the blank control group administered normal diet plus distilled water once a day,and the remaining groups were fed with high fat diet,in which the model group administered distilled water,Essentiale and low doses of Zhijuzi.The corresponding group of drugs and doses administered,once a day were observed for 90 days,respectively...