| PDGH-BB在胃癌组织中的表达及临床意义 |
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| 引用本文： | 亓军,孔亮,王连东. PDGH-BB在胃癌组织中的表达及临床意义[J]. 中国现代普通外科进展, 2013, 16(5): 366-369 |
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| 作者姓名： | 亓军 孔亮 王连东 |
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| 作者单位： | 莱芜市人民医院综合外科 山东莱芜271100 |
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| 摘 要： | 目的:检测65例胃癌患者肿瘤组织中PDGH-BB的表达情况,分析其与胃癌临床病理特征的关系及预后情况。方法:采用免疫组织化学Elivision二步法检测65例患者胃癌组织中PDGH-BB的表达,并分析其与胃癌临床病理特征及预后的关系。多因素分析患者的3年生存关系。结果:本实验中胃癌组织PDGH-BB的表达与胃癌患者的性别及胃癌肿瘤大小相关(P<0.05)。胃癌组织中黏膜细胞可见PDGH-BB阳性表达,癌旁组织中PDGH-BB的表达较弱,可见少量表达;正常胃黏膜组织基本没有表达。胃癌患者术后3年生存率为60%(39/65),其中患者肿瘤的大小及PDGH-BB阳性表达与患者3年生存期相关(P<0.05),有统计学意义。结论:胃癌组织中PDGH-BB的阳性表达,胃癌患者3年生存期多因素分析与胃癌肿瘤大小和PDGH-BB阳性表达呈正相关性。PDGH-BB与胃癌生长及转移有密切相关。
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| 关 键 词： | 胃癌 血小板衍生生长因子 临床特征 |
Expression and clinical significance of PDGH-BB in gastric carcinoma |
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| QI Jun , KONG Liang , WANG Lian-dong. Expression and clinical significance of PDGH-BB in gastric carcinoma[J]. Chinese Journal of Current Advances in General Surgery, 2013, 16(5): 366-369 |
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| Authors: | QI Jun KONG Liang WANG Lian-dong |
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| Affiliation: | (Department of General Surgery, The First Hospital of Laiwu (Laiwu 271100, China )) |
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| Abstract: | Objective： Detect PDGH-BB expression in gastric cancer and analysis the rela- tionship of PDGH-BB, clinical pathological features and the prognosis. Methods： PDGH-BB in gastric cancer was detected by the two-step way of immunohistochemistry Elivision in 65 cases to verify the expression of PDGH-BB, and to analyze its relationship with clinical and pathological fea- tures and prognosis in gastric cancer. Results： The PDGH-BB expression was positive relationship with gender and tumor size （P〈O.05）. The PDGH-BB expression was mainly found in mucosal cells in the gastric cancer tissues. The PDGH-BB expression in paraneoplastic tissues was weak, while it was basically not expressed in normal gastric mucosa cells. |
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| Keywords: | Gastric Cancer Platelet-derived Growth Factorso Pathology Characteristic |
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