CTEN与结直肠癌术后患者复发、转移及预后关系研究

目的:探讨羧基末端张力蛋白样分子(CTEN)与结直肠癌术后患者复发、转移及预后关系.方法:应用免疫组织化学检测80例结直肠癌组织以及癌旁组织中CTEN的表达,分析其不同表达与预后的关系.结果:CTEN在结直肠癌组织中表达阳性率为83.8%(67/80),癌旁组织中表达阳性率为12.5%(10/80),差异有统计学意义(P<0.01).Ⅲ+Ⅳ患者的CTEN阳性表达率明显高于Ⅰ+Ⅱ期患者(P<0.05),术后3年内复发、转移患者较无复发转移的CTEN阳性表达率高(P<0.01).Kaplan-Meier生存分析显示CTEN无表达和低表达量的结直肠癌患者预后明显好于高表达量的患者预后(P<0.01).结论:CTEN表达与术后复发、转移密切相关,有可能作为判别结直肠癌术后预后的有效预测因子.

The relationship between the level of CTEN and recurrence,metastasis and prognosis of colorectal carcinoma patients after operation

Objective:To investigate the relationship between the levels of COOH-terminus tensin-like molecule ( CTEN ) and recurrence,metastasis and prognosis of colorectal carcinoma patients after operation. Methods:The expression levels of CTEN in colorectal carcinoma tissue of 80 patients were detected using immunohistochemistry( IHC) ,and the relation of which with prognosis was analyzed. Results:The positive rates of CTEN in colorectal carcinoma tissue and paracarcinoma tissues were 83. 8%( 67/80 ) and 12. 5%(10/80),respectively,the difference of which was statistical significance(P<0. 05). The positive rates of CTEN in stages ⅢandⅣ patients were significantly higher than that in stages Ⅰ and Ⅱ patients(P<0. 05). The positive rates of CTEN in recurrence and metastases patients after 3 years of operation were higher than that in no-recurrence and metastases patients(P<0. 01). Kaplan-Meier survival analysis showed that the prognosis in no and low expression of CTEN patients were significantly better than that in high expression of CTEN patients(P<0. 01). Conclusions:The expression of CTEN is correlation with the postoperative recurrence and metastases of patients with colorectal carcinoma,which may be an effective predictor in the prognosis of colorectal carcinoma.