| 单叶细辛中一个新的马兜铃酸类化合物 |
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| 作者姓名： | Xie BB Shang MY Wang X Cai SQ Lee KH |
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| 作者单位： | 北京大学药学院天然药物与仿生药物国家重点实验室;Natural Products Research Laboratories Eshelman School of Pharmacy University of North Carolina; |
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| 基金项目： | 国家自然科学基金资助项目(30371748,30873466); 国家十一五科技支撑项目(2006BAI14B01) |
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| 摘 要： | 为了研究单叶细辛(Asarum himalaicum)的化学成分,利用溶剂提取、硅胶柱色谱、凝胶(SephadexLH-20)柱色谱和半制备型高效液相色谱(semi-preparative high performance liquid chromatography,HPLC)等手段进行分离、纯化,从单叶细辛全草中共分离鉴定了15个化合物。其结构经1H NMR、13C NMR、HR-ESI-MS等谱学方法分别鉴定为4-去甲氧基马兜铃酸BII(4-demethoxyaristolochic acid BII,1)、马兜铃酸I(aristolochicacid I,2)、马兜铃酸Ia(aristolochic acid Ia,3)、7-羟基马兜铃酸I(7-hydroxyaristolochic acid I,4)、马兜铃酸IV(aristolochic acid IV,5)、马兜铃次酸II(aristolic acid II,6)、青木香酸(debilic acid,7)、马兜铃内酰胺I(aristololactam I,8)、9-羟基马兜铃内酰胺I(9-hydroxyaristololactam I,9)、7-...
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| 关 键 词： | 单叶细辛 4-去甲氧基马兜铃酸BII 马兜铃酸 马兜铃内酰胺 |
A new aristolochic acid derivative from Asarum himalaicum |
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| Xie BB,Shang MY,Wang X,Cai SQ,Lee KH.A new aristolochic acid derivative from Asarum himalaicum[J].Acta Pharmaceutica Sinica,2011,46(2):188-192. |
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| Authors: | Xie Bai-bo Shang Ming-ying Wang Xuan Cai Shao-qing Lee Kuo-hsiung |
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| Institution: | XIE Bai-bo1,SHANG Ming-ying1,WANG Xuan1,CAI Shao-qing1,Kuo-hsiung LEE2(1.State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmacy,Peking University,Beijing 100191,China,2.Natural Products Research Laboratories,Eshelman School of Pharmacy,University of North Carolina,Chapel Hill,North Carolina 27599-7568,USA) |
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| Abstract: | To study the chemical constituents of Asarum himalaicum,fifteen compounds were isolated from a 70% ethanol extract by using a combination of various chromatographic techniques including column chromatography over silica gel,Sephadex LH-20,and semi-preparative HPLC.By spectroscopic techniques including 1H NMR,13C NMR,and HR-ESI-MS,these compounds were identified as 4-demethoxyaristolochic acid BII(1),aristolochic acid I(2),aristolochic acid Ia(3),7-hydroxyaristolochic acid I(4),aristolochic acid IV(5),aristo... |
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| Keywords: | Asarum himalaicum 4-demethoxyaristolochic acid BII aristolochic acids aristololactams |
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