| 几种亲水凝胶骨架材料相关性质的比较 |
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| 作者姓名： | Nie SF Liu H Liu YL Pan WS |
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| 作者单位： | 武汉生物工程学院制药工程系;沈阳药科大学药学院;广州军区武汉陆军总院药剂科; |
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| 摘 要： | 以茶碱为模型药物,采用直接压片法制备亲水凝胶骨架片,从骨架片吸水性、膨胀性、溶蚀性及凝胶强度4个方面,全面比较了几种亲水凝胶骨架材料羟丙甲纤维素(hydroxypropylmethylcellulose,HPMC)、聚氧化乙烯(polyethylene oxide,PEO)、海藻酸钠sodium alginate、低黏度NaAlg(L)、高黏度NaAlg(H)]和黄原胶(xanthan gum,XG)辅料性质和释药机制的差异。结果表明,吸水速率常数XG>>NaAlg(H)>PEO>NaAlg(L)>>HPMC;膨胀指数为XG>>PEO>>HPMC>>NaAlg;溶蚀速率NaAlg(L)>NaAlg(H)>>PEO80>PEO200>PEO300>XG≈PEO400≈K4M>K15M>PEO600≈K100M;凝胶层强度PEO>HPMC>XG>>NaAlg。对于PEO和HPMC骨架片,随着聚合物分子量增加,药物逐渐从以溶蚀机制为主的释放转移为以扩散机制为主的释放;对于NaAlg骨架片,药物主要以溶蚀机制释放;对于XG骨架片,药物主要以非Fick扩散机制释放。通过比较不同高分子材料之间的性能差异有助于合理设计和...
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| 关 键 词： | 聚氧化乙烯 海藻酸钠 黄原胶 羟丙甲纤维素 骨架片 |
Comparison of the characteristics of several polymer materials used in hydrophilic matrix tablets |
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| Nie SF,Liu H,Liu YL,Pan WS.Comparison of the characteristics of several polymer materials used in hydrophilic matrix tablets[J].Acta Pharmaceutica Sinica,2011,46(3):338-343. |
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| Authors: | Nie Shu-Fang Liu Hui Liu Yan-Li Pan Wei-San |
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| Institution: | NIE Shu-fang1,2,LIU Hui3,LIU Yan-li2,PAN Wei-san2(1.Department of Pharmaceutical Engineering,Wuhan Bioengineering Institute,Wuhan 430415 China,2.Department of Pharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China,3.Department of Pharmacy,Army General Hospital of Guangzhou Military Region,Wuhan 430070,China) |
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| Abstract: | Pure and drug hydrophilic matrix tablets were prepared by direct compression method with theophylline as a model drug.The characteristics of four hydrophilic matrix polymers,hydroxypropylmethylcellulose(HPMC),polyethylene oxide(PEO),sodium alginate(NaAlg) and xanthan gum(XG),were compared by investigating the water absorption,swelling,erosion and gel layer strength.The sequence of water absorption rate was XG >> NaAlg(H) > PEO > NaAlg(L) >> HPMC;The sequence of swelling index was XG >> PEO >> HPMC >> NaAlg;... |
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| Keywords: | polyethylene oxide sodium alginate xanthan gum hydroxypropylmethylcellulose matrix tablet |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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