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| 心房颤动患者循环血浆醛固酮水平及组织醛固酮合成酶的mRNA表达 | |
| 引用本文： | 王学东,吴永全,王雷,孟旭,邢云丽,胡大一.心房颤动患者循环血浆醛固酮水平及组织醛固酮合成酶的mRNA表达[J].实用临床医药杂志,2011,15(17):1-3. |
| 作者姓名： | 王学东 吴永全 王雷 孟旭 邢云丽 胡大一 |
| 作者单位： | 1. 北京市和平里医院CCU病房,北京,100013 2. 北京友谊医院心血管疾病诊治研究中心,北京,100050 3. 北京安贞医院心外科,北京,100029 4. 北京大学人民医院心内科,北京,100044 |
| 基金项目： | 中国高校医学期刊临床专项资金资助项目 |
| 摘 要： | 目的分析心房颤动患者循环血浆醛固酮(Ald)水平和心房肌组织中醛固酮合成酶(CYP11B2)的mRNA表达情况,探讨其在心房颤动发病中的作用。方法 38例因心脏疾患住院接受开胸手术的患者,分为窦性心律(SR)组,阵发房颤(pAF)组和慢性房颤(cAF)组。放射免疫方法测量循环血浆醛固酮水平,半定量聚合酶链式反应技术测定CYP11B2 mRNA在心房肌组织中的表达情况。结果 cAF组血浆Ald浓度明显高于pAF组与SR组(P<0.01);pAF组CYP11B2/GAPDH灰度比值较SR组明显升高(P<0.01),较cAF组明显降低(P<0.05)。循环血浆Ald浓度和心房肌组织CYP11B2mRNA表达水平分别与左心房直径变化具有明显的正相关关系(P<0.01)。结论 Ald可能通过介导心房结构重构,参与心房颤动的发生和维持。 |
| 关 键 词： | 心房颤动 醛固酮 醛固酮合成酶 |
The plasma level of aldsterone and the tissue expression of mRNA of aldosterone-synthase in patients with or without tatrial fibrillation |
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| WANG Xue-dong,WU Yong-quan,WANG Lei,MENG Xu,XING Yun-li,HU Da-yi.The plasma level of aldsterone and the tissue expression of mRNA of aldosterone-synthase in patients with or without tatrial fibrillation[J].Journal of Clinical Medicine in Practice,2011,15(17):1-3. | |
| Authors: | WANG Xue-dong WU Yong-quan WANG Lei MENG Xu XING Yun-li HU Da-yi |
| Institution: | 1.Beijing Hepingli Hospital,Beijing,100013;2.Beijing Friendship Hospital,Beijing,100050;3.Beijing Anzhen Hospital,Beijing 100029;4.The Affiliated People′s Hospital of Peking University,Beijing,100044) |
| Abstract: | Objective To explore the plasma level of aldosterone(Ald) and the tissue mRNA expression of aldosterone-synthase(CYP11B2) in patients with or without atrial fibrillation(AF).Methods Thirty-eight patients who underwent opened thoracic surgery were enrolled.They were divided into 3 groups according to with or without history of AF: Sinus Rhythm group,Paroxysmal AF group and Chronic AF group.The plasma concentrations of Ald were determined by the method of radio-immunity assay,and the mRNA expression of CYP11B... |
| Keywords: | atrial fibrillation aldsterone aldosterone-synthase |
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