| 替吉奥胶囊联合多西他赛治疗晚期食管癌临床疗效观察 |
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| 引用本文： | 葛伯建,高湘湘,顾寄树,谭清和. 替吉奥胶囊联合多西他赛治疗晚期食管癌临床疗效观察[J]. 实用临床医药杂志, 2011, 15(17): 102-104 |
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| 作者姓名： | 葛伯建 高湘湘 顾寄树 谭清和 |
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| 作者单位： | 江苏省南通市肿瘤医院内科,江苏南通,226001 |
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| 摘 要： | 目的观察国产替吉奥胶囊联合多西他赛治疗晚期食管癌的临床疗效和安全性。方法选择31例晚期食管癌患者,予替吉奥80 mg/m2,分2次,餐后口服,d1~d14,联合应用多西他赛25 mg/m2静脉滴注1 h,d1、d8,21 d为1个周期。观察临床疗效、不良反应,以及随访情况。结果完全缓解(CR)2例,部分缓解(PR)11例,病情稳定(SD)8例,病情进展(PD)10例,临床总缓解率(CR+PR)为41.9%,疾病控制率(CR+PR+SD)为67.7%。毒副反应主要为Ⅰ~Ⅲ度骨髓抑制、手足综合征、腹泻、轻度肝功能损伤等。中位疾病进展时间(mTTP)7.4个月,1年生存率74.2%。结论替吉奥胶囊联合多西他赛治疗晚期食管癌有一定疗效,患者耐受性好,值得临床进一步研究。
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| 关 键 词： | 食管癌 替吉奥 多西他赛 化疗 |
Clinical observation of S-1 capsule combined with Docetaxel on patients with advanced esophageal cancer |
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| GE Bo-jian,Gao Xiang-xiang,GU Ji-shu,TAN Qing-he. Clinical observation of S-1 capsule combined with Docetaxel on patients with advanced esophageal cancer[J]. Journal of Clinical Medicine in Practice, 2011, 15(17): 102-104 |
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| Authors: | GE Bo-jian Gao Xiang-xiang GU Ji-shu TAN Qing-he |
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| Affiliation: | GE Bo-jian,Gao Xiang-xiang,GU Ji-shu,TAN Qing-he(Nantong Tumor Hospital,Nantong,Jiangsu,226001) |
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| Abstract: | Objective To observe the therapeutic effect and drug tolerance of S-1 capsule combined with Docetaxel on patients with advanced esophageal cancer.Methods Thirty-one patients with advanced esophageal cancer were treated with S-1 capsule 80 mg/m2,twice daily for 14 days and Docetaxel 25 mg/m2 intravenously 1 hour on day 1 and 8.The chemotherapy was repeated every 21 days.The therapeutic effect,adverse reactions and follow-up condition were observed after treatment.Results Two cases showed complete remission(C... |
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| Keywords: | esophageal cancer S-1 Docetaxel chemotherapy |
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