替吉奥联合奥沙利铂治疗晚期结直肠癌的疗效观察

目的评价替吉奥胶囊联合奥沙利铂治疗晚期结直肠癌的近期疗效及毒副反应。方法 52例晚期结直肠癌患者采用替吉奥联合奥沙利铂治疗,替吉奥胶囊80 mg/(m2.d),分2次餐后口服,d1~14。奥沙利铂130 mg/m2,静脉滴注,滴注时间3~6 h,d1。4周为1个周期。治疗3周期评价疗效。结果 52例患者总有效率为48.1%。完全缓解(CR)2例,占全部患者的3.8%;部分缓解(PR)23例,44.2%;稳定(SD)18例,34.6%;进展(PD)9例,17.3%。主要毒副作用为消化道反应、骨髓抑制,末梢神经炎等,无患者死亡。结论替吉奥胶囊联合奥沙利铂治疗晚期结直肠癌疗效好,毒副作用相对较低,值得临床推广。

The therapeutic effect of compound Tegafur capsules plus Oxaliplatin for the treatment of advanced colorectal cancer

Objective To evaluate the therapeutic effect and side effects of S-1 plus Oxaliplatin for the treatment of advanced colorectal cancer(ACC).Methods Fifty-two ACC patients received compound Tegafur capsules 80 mg/(m2·d),oral administration,two times a day,days 1~14,plus Oxaliplatin(at a dose of 130 mg per square meter of body-surface area per day,as a 3~6 h intravenous guttae for 1 day) every 4 weeks for a minimum of 3 cycles.Results Total effective rate was 48.1%,among which 2 patients showed complete response(3.8%),23 patients showed partial response(44.2%),18 patients showed stable disease(34.6%),and 19 patients showed disease progression(17.3%).The main side effects observed included gastrointestinal reaction,bone marrow depression and peripheral neuritis.No death rate was reported.Conclusion Compound Tegafur capsules plus Oxaliplatin with comparatively lower side effects could be a preferred method for patients with ACC.