| 新生儿缺氧缺血性脑病颅脑MRI-Apgar评分、血清NSE相关性研究 |
| |
| 引用本文： | 丁燕霞,李晓春. 新生儿缺氧缺血性脑病颅脑MRI-Apgar评分、血清NSE相关性研究[J]. 实用临床医药杂志, 2011, 15(17) |
| |
| 作者姓名： | 丁燕霞 李晓春 |
| |
| 作者单位： | 安徽医科大学附属安庆医院儿科,安徽安庆,246003 |
| |
| 基金项目： | 安徽高校省级自然科学研究项目，中国高校医学期刊临床专项资金资助项目 |
| |
| 摘 要： | 目的 探讨新生儿缺氧缺血性脑病(HIE)颅脑磁共振成像(MRI)改变与血清神经元特异性烯醇化酶(NSE)及新生儿评分(Apgar评分)之间的关系.方法 选取HIE患儿100例(早产儿50例,足月儿50例)为实验组,依据颅脑MRI表现程度分为轻度HIE和中重度HIE组；另选同期非HIE新生儿40例为对照组,均在其生后行Apgar评分、检测血清NSE浓度,并于生后3～7 d行颅脑MRI检查.结果 HIE足月儿和早产儿随着MRI表现程度加重,血清NSE值逐渐增高,Apgar评分逐渐降低.中重度组与轻度组、对照组相比NSE水平差异显著,但轻度组与对照组差异不明显.5min Apgar评分两两比较差异明显.结论 外周血清NSE值与Apgar评分可作为临床早期评价HIE新生儿脑损伤严重程度的客观指标,且与头颅MRI分度基本一致.临床上可通过2指标的评定对HIE患儿进行早期诊断与干预.
|
| 关 键 词： | 新生儿缺氧缺血性脑病 颅脑MRI Apgar评分 神经元特异性烯醇化酶 |
Study on brain MRI and its relations to Apgar scores, serum level of NSE in patients with neonatal hypoxic ischemic encephalopathy |
| |
| DING Yan-xia,LI Xiao-chun. Study on brain MRI and its relations to Apgar scores, serum level of NSE in patients with neonatal hypoxic ischemic encephalopathy[J]. Journal of Clinical Medicine in Practice, 2011, 15(17) |
| |
| Authors: | DING Yan-xia LI Xiao-chun |
| |
| Affiliation: | DING Yan-xia,LI Xiao-chun(Anqing Hospital Affiliated to Anhui Medical University,Anqing,Anhui,246003) |
| |
| Abstract: | Objective To investigate the change of cerebral MRI of neonatal Hypoxic Ischemic Encephalopathy(HIE),and the relation between the serum neuron-specific enolase(NSE) and Apgar scores.Methods One hundred HIE cases were chosen as experimental group,including 50 preterm cases and 50 term neonates.Based the degree of MRI,the subjects in the experimental group were classified into HIE mild and HIE moderate and severe.Another forty normal ones were chosen as control group.Blood samples were collected in all the re... |
| |
| Keywords: | neonatal hypoxic ischemic encephalopathy cerebral MRI Apgar score neuron-specific enolase |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
