| 丙烯酸树脂水性包衣工艺制备氯化钾缓释片的研究 |
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| 引用本文： | 包泳初,陈挺,瞿挺,陈庆华. 丙烯酸树脂水性包衣工艺制备氯化钾缓释片的研究[J]. 中国药师, 2004, 7(10): 790-791 |
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| 作者姓名： | 包泳初 陈挺 瞿挺 陈庆华 |
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| 作者单位： | 1. 上海医药工业研究院,上海,200040
2. 德国Glatt公司 |
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| 摘 要： | 目的:研究氯化钾缓释片的优化工艺.方法:采用丙烯酸树脂水性包衣工艺,通过体外溶出试验对工艺参数进行筛选.结果:包衣后热处理、包衣处方因数(聚合物配比、增塑剂、包衣增重等)都对缓释片释放度有影响,而浆法转速和介质渗透压对缓释片释放度几乎无影响.结论:本研究缓释片的体外释放按零级模式释药.
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| 关 键 词： | 氯化钾 工艺学,制药 缓释片 体外释放 |
| 文章编号： | 1008-049X(2004)09-0790-02 |
| 修稿时间： | 2003-09-08 |
Study on Technology of Potassium Chloride Sustained-release Tablets Coated With Aqueous Dispersion |
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| Bao Yongchu,Chen Ting,Qu Ting,Chen Qinghua. Study on Technology of Potassium Chloride Sustained-release Tablets Coated With Aqueous Dispersion[J]. China Pharmacist, 2004, 7(10): 790-791 |
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| Authors: | Bao Yongchu Chen Ting Qu Ting Chen Qinghua |
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| Affiliation: | Bao Yongchu 1,Chen Ting 2,Qu Ting 1,Chen Qinghua 1 |
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| Abstract: | Objective: The optimized formulation of potassium chloride(KCl) sustained release tablets(SR) was investigated.Method: Aqueous acrylic polymeric dispersion(Eudragit RS/RL)was used as a film material. Technological parameters of tablets in coating process were screened by dissolution tests.Result: Eudragit RS/RL ratio, plasticizers, layer weight and curing condition after coating were proven to be a rate limited factors and drug release rate was less influenced by stirring rate and osmotic pressure of medium.Conclusion: Releasing rate of KCl from tablets was demonstrated in accordance with zero profile. |
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| Keywords: | Potassium chloride Aqueous coating process Sustained release tablets Dissolution |
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