|
|||||
|
|
| 黄芩苷元对小鼠四氯化碳肝损伤的保护作用 | |
| 引用本文： | 刘建新,谢水祥,周俐,汪秀荣,杨庆春,张文平.黄芩苷元对小鼠四氯化碳肝损伤的保护作用[J].时珍国医国药,2007,18(4):798-799. |
| 作者姓名： | 刘建新 谢水祥 周俐 汪秀荣 杨庆春 张文平 |
| 作者单位： | 1. 赣南医学院药理教研室,江西,赣州,341000 2. 赣南医学院原生物学教研室,江西,赣州,341000 3. 赣南医学院机能实验室,江西,赣州,341O00 |
| 基金项目： | 江西省自然科学基金项目(No.0440013) |
| 摘 要： | 目的探讨黄芩苷元对小鼠CCl4肝损伤的保护作用。方法采用CCl4小鼠急性肝损伤模型,测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性、肝组织MDA含量,并观察肝组织病理变化。结果黄芩苷元能保护CCl4所致小鼠肝损伤,表现为血清ALT,AST活力和肝脏MDA含量下降,同时其肝脏病变较模型组为轻。结论黄芩苷元对CCl4所致小鼠肝损伤具有保护作用。 |
| 关 键 词： | 黄芩苷元 肝损伤 保护作用 |
| 文章编号： | 1008-0805(2007)04-0798-02 |
| 修稿时间： | 2006年9月6日 |
Protective Effect of Baitalein on Experimental Liver Injury in Mice |
|
| LIU Jian-xin,XIE Shui-xiang,ZHOU Li,WANG Xiu-rong,YANG Qing-chun,ZHANG Wen-ping.Protective Effect of Baitalein on Experimental Liver Injury in Mice[J].Lishizhen Medicine and Materia Medica Research,2007,18(4):798-799. | |
| Authors: | LIU Jian-xin XIE Shui-xiang ZHOU Li WANG Xiu-rong YANG Qing-chun ZHANG Wen-ping |
| Institution: | LIU Jian-xin1,XIE Shui-xiang2,ZHOU Li3,WANG Xiu-rong3,YANG Qing-chun2,ZHANG Wen-ping2 |
| Abstract: | Objective To investigate the protective effect of baicalein against carbon tetrachloride(CCl4)-induced hepatotoxicity in mice.Methods The experimental model of liver injury was induced by CCl4 in mice.The serum alanine aminotransferase(ALT),aspartate aminotransferase(AST) and liver malondialdehyde(MDA) were determined.The pathological examination of liver was performed.Results Baicalein significantly reduced serum ALT, AST activities and liver MDA content,and the liver lobule were ameliorated obviously.Conclusion Baicalein has a protective effect on acute hepatic injury induced by CCl4. |
| Keywords: | Baicalein Hepatotoxicity Hepatic-protection |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |