| Variations and Clinical Significance of Coagulation and Fibrinolysis Parameters in Patients with Diabetes Mellitus |
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| 作者姓名： | 胡俊斌 魏文宁 丁桂芝 袁莉 刘仲萍 |
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| 作者单位： | HU Junbin，WEI Wenning，DIN GuizhiYUAN Li，LIU ZhongpinInstitute of Hematology，Tongji Medical University，Wuhan 430022Department of Endocrinology，Xiehe Hospital，Tongji Medical University，Wuhan 430022 |
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| 摘 要： | We observed the changes of parameters of coagulation and fibrinolytic system in order to understand the clinical implication of these variations in type diabetic patients. Subjects consisted of 22 patients with type Ⅱ diabetes mellitus and 25 healthy controls. Compared with the control, activated partial thromboplastin time, prothrombin time were shortened in the patients. The diabetic subjects also displayed higher levels of D-dimer, serum fibrin degradation products,median concentrations of fibrinogen (3.99 vs 2.96 g/L, P<0.01) and yon Willebrand factor (149% vs 87%, P<0.01). Levels of antithrombin Ⅲ activity or antigen were not different from control values. Simple linear regression analysis revealed a negative correlation between antithrombin Ⅲ activity and fast blood glucose. Diabetic patients with vascular complications had significantly higher levels of fibrinogen and D-dimer than those without diabetic angiopathy. Our data demonstrated that patients with type Ⅲ diabetes mellitus had a hyperco
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| 收稿时间： | 10 February 1998 |
Variations and clinical significance of coagulation and fibrinolysis parameters in patients with diabetes mellitus |
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| Hu Junbin,Wei Wenning,Din Guizhi,Yuan Li,Liu Zhongpin.Variations and Clinical Significance of Coagulation and Fibrinolysis Parameters in Patients with Diabetes Mellitus[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1998,18(4):233-235. |
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| Authors: | Hu Junbin Wei Wenning Din Guizhi Yuan Li Liu Zhongpin |
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| Institution: | (1) Institute of Hematology, Tongji Medical University, 430022 Wuhan;(2) Department of Endocrinology, Xiehe Hospital, Tongji Medical University, 430022 Wuhan |
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| Abstract: | Summary We observed the changes of parameters of coagulation and fibrinolytic system in order to understand the clinical implication
of these variations in type I diabetic patients. Subjects consisted of 22 patients with type I diabetes mellitus and 25 healthy
controls. Compared with the control, activated partial thromboplastin time, prothrombin time were shortened in the patients.
The diabetic subjects also displayed higher levels of D-dimer, serum fibrin degradation products, median concentrations of
fibrinogen (3. 99 vs 2. 96 g/L,P<0. 01) and von Willebrand factor (149 % vs 87 %,P<0.01). Levels of antithrombin activity or antigen were not different from control values. Simple linear regression analysis
revealed a negative correlation between antithrombin activity and fast blood glucose. Diabetic patients with vascular complications
had significantly higher levels of fibrinogen and D-dimer than those without diabetic angiopathy. Our data demonstrated that
patients with type I diabetes mellitus had a hypercoagulable state. We believed the activation of coagulation might contribute
to the vascular complications in diabetics. |
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| Keywords: | diabetes mellitus hypercoagulability vascular complication |
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