非酒精性脂肪肝性别之间血清生化指标比较

目的比较非酒精性脂肪肝患者性别之间生化代谢差异,探讨预防控制策略。方法检测973名体检者的总蛋白(TP)、白蛋白(ALB)、球蛋白(GLO)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、葡萄糖(GLU)、总胆固醇(T-CHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(apoA1)、载脂蛋白B100(apoB100),计算non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、TC/HDL-C比值,并对89例非酒精性脂肪肝与202名体检健康者(对照组)进行比较。结果脂肪肝患病率为9.05%,男性患病率12.53%,显著高于女性的6.0%(P<0.05);与对照组比较,59例男性患者的ALT、IBIL、TG、HDL-C、LDL-C、apoA1、non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、TC/HDL-C差异有统计学意义(P<0.05,P<0.01),30例女性患者的AST、TBIL、DBIL、IBIL、GLU、T-CHO、TG、LDL-C、apoA1、non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、TC/HDL-C差异具有统计学意义(P<0.05,P<0.01);non-HDL-C与TC、LDL-C、TG、HDL-C、apoA1、apoB100、apoB100/apoA1、TC/HDL均显著相关(相关系数0.4113~0.9893,P<0.01)。结论非酒精性脂肪肝普遍具有代谢异常和肝脏受损特点,且性别之间表现不同,应采取针对性措施进行必要的预防和干预。

Comparison of the Serum Biochemical Marks between Male and Female Nonalcoholic Fatty Liver Patients

[Objective] To compare the differences of biochemical metabolism between male and female nonalcoholic fatty liver patients and explore preventive countermeasures.[Methods] Detection was made on the levels of TP,ALB,GLO,AST,ALT,TBIL,DBIL,IBIL,GLU,T CHO,TG,HDL C,LDL C,apoA1 and apoB 100 among 973 people who undertook physical examination; calculation was made on non HDL C and the ratio of apoB 100/apoA1,LDL C/HDL C, apoB 100/HDL C and TC/HDLC;comparison was made on the result between 59 nonalcoholic fatty liver patients and 202 healthy people in the control.[Results] The total morbidity of fatty liver was 9.05%,the rate of the male patients was 12.53%,which was significantly higher than that of the female ones(6.0%)(P<0.05);significant difference was found among the 59 male patients in the levels of ALT,IBIL,TG,HDL C,LDL C,apoA1,non HDL C and the ratio of apoB 100/apoA1,LDL C/HDL C,apoB 100/HDL C and TC/HDLC(P<0.05,P<0.01);significant difference was also found among the 30 female patients in the levels of AST,TBIL,DBIL,IBIL,GLU,T CHO,TG,LDL C,apoA 1,non HDL C,and the ratios of apoB100/apoA1,LDL C/HD C,apoB 100/HDLC and TC/HDLC(P<0.05, P<0.01);non HDL C was obviously correlated with TC,LDLC,TG,HDLC,apoA1, apoB100,apoB100/apoA1 and TC/FIDLC(r=0.4113~0.9893,P<0.01).[Conclusion] Metabolism disorder and liver damage are the common features of nonalcoholic fatty liver and there are significant differences between males and females;effective measure should be taken for the prevention and interference.