Prognostic role of osteopontin expression in malignant pleural mesothelioma |
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| Authors: | Cappia Susanna Righi Luisella Mirabelli Dario Ceppi Paolo Bacillo Elisa Ardissone Francesco Molinaro Luca Scagliotti Giorgio V Papotti Mauro |
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| Affiliation: | Department of Clinical and Biological Sciences, University of Torino at St Luigi Hospital, Torino, Italy. |
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| Abstract: | Malignant pleural mesothelioma (MPM) represents highly aggressive neoplasms with a mean survival of approximately 10 months. Osteopontin, a glycoprotein involved in cell-matrix interactions correlated with invasion and metastatic spread in several tumors, has recently been proposed as a serum marker of MPM in asbestos-exposed subjects. The aim of this study was to define the prognostic role of osteopontin in MPM. For the study, 32 long-term survivors (>24 months) and a random sample of 69 short-term survivors (
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