1,6-二磷酸果糖治疗新生儿缺氧缺血性脑病的临床观察

目的观察1,6-二磷酸果糖对新生儿缺氧缺血性脑病的治疗作用。方法78例缺氧缺血性脑病患儿随机分为两组,治疗组在常规治疗基础上给予1,6-二磷酸果糖,对照组采用常规治疗。结果治疗组显效率为83.3%,对照组为55.6%;治疗组总有效率为97.6%,对照组为88.9%。两组疗效比较有显著性差异(P<0.05)。1,6-二磷酸果糖还能明显降低血清CK、CKMB、HBDH的浓度。结论1,6-二磷酸果糖治疗新生儿缺氧缺血性脑病有效率高,能起到加快脑损伤恢复及减少心肌损害的双重作用,且无明显的副作用。

Clinical effects of fructose 1,6 - diphosphate in newborn with hypoxic - ischemic encephalopathy

Objective To study the treatment effects of fructose 1,6-diphosphate (FDP) on newborn with hypoxic-ischemic encephalopathy (HIE).Methods A total of 78 newborns with HIE were randomly divided into two groups. In control group ( n =42) , the treatment was common. In FDP group ( n =36) ,FDP 250 mg/ (kg·d) was injected by intravenous drip continued 10-14 days except for routine therapy.Results Compared to the controls, the treatment effects were better in the FDP group. There were statistically significant differences in the treatment effects between two groups (P<0.05). The total effective rate of controls and FDP group were 97.6% and 88.9% respectively. Moreover, FDP could obviously decrease the CK、CKMB、HBDH in serum in the newborns with HIE.Conclusion FDP can be effectively used for treating in newborns with HIE. It could improve brain damage and reduce cardiac damage, without significant adverse reaction.