血糖调节受损者糖化白蛋白与心血管危险因子的相关性

目的探讨血糖调节受损者糖化白蛋白(GA)与强预测因子高敏C反应蛋白(hsCRP)水平和总胆固醇/高密度脂蛋白胆固醇比值(TC/HDL ratio)的分布特征。方法受试者行口服葡萄糖耐量试验(OGTT),同时检测空腹GA、hsCRP、TC和HDL水平。按2005年中华医学会糖尿病分会提出的血糖调节受损诊断标准,将所有受试者分为5组:糖耐量正常组、血糖调节受损组(包括单独空腹血糖受损组、单独糖耐量异常组、空腹血糖受损和糖耐量异常联合组)、糖尿病组,比较各组间GA、hsCRP、TC/HDL ratio和OGTT血糖曲线下面积的差异,并进一步分别按hsCRP、TC/HDL ratio四分位水平分组,分析各组GA水平的差异。结果血糖调节受损组及糖尿病组GA、hsCRP、TC/HDL ratio和OGTT血糖曲线下面积与糖耐量正常组之间有统计学差异(P<0.01);GA水平随hsCRP水平和TC/HDL ratio上升而明显升高(P<0.01)。结论初诊糖尿病患者和血糖调节受损者GA水平随hsCRP水平和TC/HDL ratio的升高而上升,其对糖尿病患者远期心血管事件的发生可能有一定的预测作用。

Correlation between glycated albumin and coronary artery disease risk factors in patients with impaired glucose regulation

Objective To study the profile of serum glycated albumin(GA) level,high sensitivity C-reactive protein(hsCRP) level and total cholesterol/high-density lipoprotein cholesterol ratio(TC/HDL ratio). Methods Oral glucose tolerance test(OGTT) was performed and fasting GA,hsCRP,TC and HDL were detected.All participants were divided into five groups according to the criteria for impaired glucose regulation put forward by the Diabetes Mellitus(DM) Branch of Chinese Medical Association,including patients with normal glucose tolerance(NGT group),patients with impaired glucose regulation(IGR)(impaired fasting glucose group,IFG group;impaired glucose tolerance group,IGT group;IFG/IGT group) and patients with DM(DM group).The differences of GA level,hsCRP level,TC/HDL ratio and area under the curve of blood glucose were compared.Subgroups were divided in line with the quartile level of hsCRP and TC/HDL ratio,respectively,and the differences of GA level were evaluated. Results There were significant differences in GA level,hsCRP level,TC/HDL ratio and area under the curve of blood glucose between IGR patients and NGT group(P<0.01),and the GA level went up markedly with hsCRP level and TC/HDL ratio(P<0.01). Conclusion The level of GA increases with the hsCRP level and TC/HDL ratio in patients with DM or IGR,which may serve as a predicator for long-term cardiovascular events in patients with DM.