Ezrin蛋白在结肠癌组织中的表达及意义

目的进一步探讨结肠癌的发生、发展机制。方法应用免疫组织化学染色法检测69份结肠癌组织及其对应癌旁良性组织、23份转移淋巴结组织中Ezrin蛋白、Ki-67蛋白表达，分析Ezrin蛋白表达与结肠癌临床病理特征及Ki-67蛋白表达的关系。结果Ezrin、Ki-67蛋白在结肠癌组织及转移淋巴结组织中的阳性表达率均明显高于癌旁组织（P均〈0．01），Ezrin蛋白在结肠癌组织中的表达与组织分化程度及有无淋巴结转移、浆膜侵犯有关（P均〈0．01）；Ezrin蛋白与Ki-67蛋白表达呈显著正相关，P〈0．05（r=0．317）。结论Ezrin蛋白在结肠癌发生、发展中起重要作用；此为结肠癌的分子靶向治疗提供了依据。

Expression of Ezrin protein in colon cancer tissue and its significance

Objectives To further explore the occurrence and development mechanism of colon cancer. Methods Immunohistochemical technique was adopted to detect the protein expression level of Ezrin protein and Ki-67 protein in 69 cases of colon cancer, adjacent tumor tissues, and 23 lymph gland tissues, meanwhile the relationship between the expression of Ezrin and the clinical pathologic factors, the expression of Ki-67 protein were analyzed. Results Ezrin and Ki-67 protein positive expression rate in the normal mucosa significant were both lower than those in the tumor tissues and lymph gland tissues （all P 〈 0.01 ）. The Ezrin protein positive expression rate was related with the differentiation, LNM, and se- rous infringed（ all P 〈0.01 ）. Ezrin protein expression in colorectal tissues was positively correlated with Ki-67 protein expression in colon cancer, P 〈 0.05 （ r = 0.317）. Conclusions Ezrin protein play an important role in the occurrence and development of colon cancer. This study can provide basis for the molecular target therapy of colon cancer.