| 国产洛哌胺对胃肠运动及肠肌电的作用 |
| |
| 引用本文： | 余颂涛,陈伟,陈国志,陶国枢.国产洛哌胺对胃肠运动及肠肌电的作用[J].军医进修学院学报,1990(1). |
| |
| 作者姓名： | 余颂涛 陈伟 陈国志 陶国枢 |
| |
| 作者单位： | 老年医学研究所,老年医学研究所,军事医学科学院二所,老年医学研究所 |
| |
| 摘 要： | 国产洛哌胺抑制小鼠胃肠运动的ID_(50)为0.957mg/kg,抑制组织胺引起离体豚鼠回肠的ID_(50)为0.765mg/L,分别比吗啡的抑制作用强10.85和22.18倍。洛哌胺2mg/kg使清醒大鼠十二指肠、空肠和回肠的肌电峰电位振幅明显减少,持续2小时仍未见有所恢复,大剂量洛哌胺并不引起吗啡样行为反应,结果表明洛哌胺是一高效、安全的胃肠运动抑制剂。
|
| 关 键 词： | 洛哌胺 吗啡类 胃肠活动 肠肌电 小鼠 |
The effect of loperamide on gastro-intestinal motility and intestinal myoelectrical activity |
| |
| Yu Songtao,et al.The effect of loperamide on gastro-intestinal motility and intestinal myoelectrical activity[J].Academic Journal of Pla Postgraduate Medical School,1990(1). |
| |
| Authors: | Yu Songtao |
| |
| Abstract: | In the "Charcaol test", the ID5O of loperamide was found to be 0.957 mg/kg s. c. loperamide is an agent devoid of morphinelike behavior, even at toxic dose level (80mg/kg s. c. ). It has a potent antagonist action upon histamine-induced contraction of the guinea-pig ileum and can decrease the amplitude and number of spiks of duodenum, ejjunum and ileum myoelectrical activity. It is also a potent and safe inhibitor of gastro-intestinal motilily. |
| |
| Keywords: | Loperamide Morphine Gastrointestinal motility Intestinal myoelectrical Mice |
| 本文献已被 CNKI 等数据库收录！ |
|
