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双黄连对α2a-干扰素抗柯萨奇病毒的协同作用
引用本文:吕海涛,杨吉成,袁志昌,盛伟华,严文华. 双黄连对α2a-干扰素抗柯萨奇病毒的协同作用[J]. 中国中药杂志, 2000, 25(11): 682-684
作者姓名:吕海涛  杨吉成  袁志昌  盛伟华  严文华
作者单位:苏州医学院附属儿童医院!江苏苏州215003(吕海涛,袁志昌,严文华),苏州医学院基因室!江苏苏州215007(杨吉成,盛伟华)
摘    要:目的:探讨双黄连对rIFN-α2a抗柯萨奇病毒的影响。方法:采用微量细胞病变抑制法在Wish和Vero细胞上进行双黄连、rIFN-α2a及两者联用抗柯萨奇病毒(CVB3)的实验研究。结果:两药联用抗柯萨奇病毒呈明显协同作用;0.125 mg.ml-1的双黄连可使干扰素(rIFN-α2a)在Wish和Vero细胞上抗柯萨奇病毒的效价提高2.58倍左右。结论:该结果为临床中西医结合治疗柯萨奇病毒感染提供新的配伍。

关 键 词:双黄连  α2a-干扰素(rIFN-α2a)  柯萨奇病毒B3型(CVB3)
收稿时间:2000-01-17

Effect of combined treatment of Shuanghuanglian and recombinant interferon alpha 2a on coxsackievirus B3 replication in vitro]
LU Hai-tao;YUAN Zhi-chang;YAN Weng-hua;YANG Ji-cheng;SHENG Wei-hua. Effect of combined treatment of Shuanghuanglian and recombinant interferon alpha 2a on coxsackievirus B3 replication in vitro][J]. China Journal of Chinese Materia Medica, 2000, 25(11): 682-684
Authors:LU Hai-tao  YUAN Zhi-chang  YAN Weng-hua  YANG Ji-cheng  SHENG Wei-hua
Affiliation:Affiliated Children's Hospital of Suzhou Medical College, Suzhou 215003, Jiangsu, China.
Abstract:OBJECTIVE: To investigate the effect of combined treatment of Shanghanglian (SHHL) and recombinant interferon alpha 2a on Coxsackie virus B3 replication. METHODS: Microdose cytopathogenic inhibition effect assay was used in Wish and Vero cultured cells. rIFN-alpha 2a was applied 12 hours before Coxsackievirus B3 inoculation and SHHL was applied 1 hour after Coxsackievirus B3 inoculation. RESULTS: 0.125 mg.ml-1 SHHL has a synergism with rIFN-alpha 2a to inhibit CPE caused by Coxsackievirus B3 on the Wish and Vero cells. The anti-cox-sackievirus activity of combined treatment was 2.58 times higher than that of rIFN-alpha 2a treatment. CONCLUSION: This combined treatment of drugs may be useful in preventing and treating Coxsackie B3 Virus infection.
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