中西医结合治疗急性冠脉综合征的临床疗效及对血清CRP,IL-6的影响

目的: 探讨中西医结合治疗急性冠脉综合征的临床疗效及对血清超敏C-反应蛋白(hs-CRP)和白细胞介素-6(IL-6)的影响。 方法: 将118例急性冠脉综合征患者随机分入对照组与观察组,其中对照组患者接受常规西医治疗,观察组患者接受西医联合中药治疗,给予黄芪注射液40 g及丹参注射液20 mL分别加入0.9%氯化钠注射液250 mL中静点,每日1次,疗程2周。比较两组临床疗效、血脂及血清hs-CRP及IL-6的差别。 结果: 治疗后观察组治疗总有效率显著高于对照组(91.7% vs 75.9%,P<0.05);治疗后观察组硝酸甘油用量显著少于对照组(1.47±0.52) vs (3.40±0.87)片/周,P<0.05],治疗后两组中医证候评分均显著下降,但观察组评分显著低于对照组(0.90±0.26) vs (1.33±0.41)分,P<0.05];治疗后观察组血清胆固醇(TC)、甘油三酯(TG)、hs-CRP及IL-6分别为(4.89±0.96),(1.60±0.52) mmol·L^-1,(5.76±0.97) mg·L^-1,(76.59±14.38) ng·L^-1,显著低于对照组(5.90±1.13),(1.84±0.67) mmol·L^-1,(7.36±1.03) mg·L^-1,(102.85±19.88) ng·L^-1 (P<0.05)。 结论: 在西医治疗基础上给予中医治疗,可显著降低患者血清炎症因子及血脂,提高临床疗效。

Clinical Effect of Traditional Chinese and Western Medicine for Acute Coronary Syndrome and Influence for Serum hs-CRP and IL-6

Objective: To explore the clinical effect of traditional Chinese and western medicine for acute coronary syndrome and the influence for serum high-sensitivity C-reactive protein(hs-CRP) and interleukin-6(IL-6).Method: One hundred and eighteen cases with acute coronary syndrome were randomly divided into control group and experience group. Control group were given routine western medicine and experience group were administrated with traditional Chinese and western medicine. 40 g Huangqi injection and 20 mL Danshen injection were dissolved into 250 mL sodium chloride injection respectively, quiescent point, once a day. The course of treatment was 2 weeks.Result: After treatment, the effective rates was much higher than that in control group (91.7% vs 75.9%,P<0.05);the dose of nitroglycerin in experience group was (1.47±0.52) tablets/week, of which was much less than that in control group(3.40±0.87) tablets/week, P<0.05)]. After treatment, tcm syndrome evaluation in two groups were both decreased, while the tcm syndrome evaluation in experience group was superior to control group(0.90±0.26) vs (1.33±0.41)paper,P<0.05]. The serum triglyceride(TC),total cholesterol(TG), hs-CRP and IL-6 after therapy in experience group were (4.89±0.96),(1.60±0.52) mmol·L^-1, (5.76±0.97) mg·L^-1 and (76.59±14.38) ng·L^-1,and of the above indexes in control group were (5.90±1.13), (1.84±0.67) mmol·L^-1, (7.36±1.03) mg·L^-1 and (102.85±19.88) ng·L^-1 with significant difference between two groups(P<0.05).Conclusion: Traditional Chinese and western medicine for acute coronary syndrome greatly decrease the serum inflammatory factor and blood lipid, and improve the clinical effect.