| 独一味环烯醚萜苷胶囊质量标准研究 |
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| 引用本文： | 尉丽力,邱建国,李茂星,张泉龙,周珺,贾正平. 独一味环烯醚萜苷胶囊质量标准研究[J]. 中国实验方剂学杂志, 2013, 19(22): 137-140 |
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| 作者姓名： | 尉丽力 邱建国 李茂星 张泉龙 周珺 贾正平 |
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| 作者单位： | 兰州军区兰州总医院药剂科, 全军高原环境损伤防治重点实验室, 兰州 730050;兰州军区兰州总医院药剂科, 全军高原环境损伤防治重点实验室, 兰州 730050;兰州军区兰州总医院药剂科, 全军高原环境损伤防治重点实验室, 兰州 730050;兰州军区兰州总医院药剂科, 全军高原环境损伤防治重点实验室, 兰州 730050;兰州军区兰州总医院药剂科, 全军高原环境损伤防治重点实验室, 兰州 730050;兰州军区兰州总医院药剂科, 全军高原环境损伤防治重点实验室, 兰州 730050 |
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| 基金项目： | 甘肃省科技重大专项(1102FKDA012) |
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| 摘 要： | 目的: 制定独一味环烯醚萜苷胶囊的质量标准。 方法: 以薄层色谱法对本品主成分进行定性鉴别,采用一阶导数法测定总环烯醚萜苷含量,高效液相色谱法测定山栀苷甲酯、8-O-乙酰山栀苷甲酯的含量。 结果: 薄层色谱法样品与对照品在相同位置斑点清晰;一阶导数分光光度法测得3批总环烯醚萜苷含量均>50%;山栀苷甲酯、8-O-乙酰山栀苷甲酯与其他组分基线分离且峰形较好,测得3批样品平均含量为73.96,72.43 mg·g-1。 结论: 该方法可以用于独一味环烯醚萜苷胶囊的质量控制。
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| 关 键 词： | 独一味 环烯醚萜苷胶囊 质量标准 |
| 收稿时间： | 2013-07-26 |
Quality Standard of Iridoid Glycosides Capsule of Lamiophlomis rotata. |
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| WEI Li-li,QIU Jian-guo,LI Mao-xing,ZHANG Quan-long,ZHOU Jun and JIA Zheng-ping. Quality Standard of Iridoid Glycosides Capsule of Lamiophlomis rotata.[J]. China Journal of Experimental Traditional Medical Formulae, 2013, 19(22): 137-140 |
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| Authors: | WEI Li-li QIU Jian-guo LI Mao-xing ZHANG Quan-long ZHOU Jun JIA Zheng-ping |
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| Affiliation: | Department of Pharmacy, Lanzhou General Hospital of PLA; Key Laboratory of the Prevention and Cure for the Plateau Environment Damage, PLA, Lanzhou 730050, China;Department of Pharmacy, Lanzhou General Hospital of PLA; Key Laboratory of the Prevention and Cure for the Plateau Environment Damage, PLA, Lanzhou 730050, China;Department of Pharmacy, Lanzhou General Hospital of PLA; Key Laboratory of the Prevention and Cure for the Plateau Environment Damage, PLA, Lanzhou 730050, China;Department of Pharmacy, Lanzhou General Hospital of PLA; Key Laboratory of the Prevention and Cure for the Plateau Environment Damage, PLA, Lanzhou 730050, China;Department of Pharmacy, Lanzhou General Hospital of PLA; Key Laboratory of the Prevention and Cure for the Plateau Environment Damage, PLA, Lanzhou 730050, China;Department of Pharmacy, Lanzhou General Hospital of PLA; Key Laboratory of the Prevention and Cure for the Plateau Environment Damage, PLA, Lanzhou 730050, China |
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| Abstract: | Objective: To establish the quality standard of iridoid glycosides capsule of Lamiophlomis rotata (IGC). Method: The iridoid glycosides capsule of L. rotata was identified by TLC. The contents of total iridoid glycosides, shanzhiside methyl ester and 8-O-acetylshanzhiside methyl ester in the capsule were determined by the first derivating UV-spectra and HPLC. Result: The identify spots were clear in TLC, and the constituents were well separated under the chromatographic condition. The contents of total iridoid glycosides of three batch capsule were more than 50%, the shanzhiside methyl ester and 8-O-acetylshanzhiside methyl ester were separated with other composition and the content were 73.96,72.43 mg·g-1 respectively. Conclusion: The method can be used to control the quality of IGC. |
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| Keywords: | Lamiophlomis rotata iridoid glycosides capsule quality standard |
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