肿瘤标志物在卵巢肿瘤的诊断及良、恶性鉴别中的作用分析

目的：分析肿瘤标志物在卵巢肿瘤（Ovarian Tumors,OT）的诊断及良、恶性鉴别中的作用,为卵巢肿瘤的诊断提供理论依据.方法：选取我院2007年9月至2010年3月收治的171例OT患者,按照其肿瘤良、恶性分为良性组（n=94）和恶性组（n=77）,并选取同期门诊健康体检妇女80名纳入对照组,对比三组受检者肿瘤标志物水平的差异.结果：OT患者CA125、CA153、CA199、CA242、CEA、铁蛋白等肿瘤标志物水平均显著高于对照组人群,恶性组患者上述肿瘤标志物水平亦高于良性组患者（P＜0.05）,三组人群NSE、β-HCG、AFP、PSA、f-PSA及HCG水平无明显统计学差异（P＞0.05）;恶性组CA125、CA153、CA199、CA242、CEA、铁蛋白、β-HCG、AFP、HGH阳性率均显著高于良性组及对照组,三组人群CA125、CA199、CA242、CEA、铁蛋白、β-HCG、AFP及HGH阳性率存在显著统计学差异（P＜0.05）.结论：CA125、CA199、CA242、CEA、铁蛋白、β-HCG、AFP及HGH等肿瘤标志物在OT的诊断及良、恶性鉴别中具有较好的效果,随着肿瘤标志物水平和阳性率的上升,提示患者OT进展程度更高、肿瘤恶性风险增加,选择CA125、CA199和CEA进行联合检测,可在降低成本的同时得到良好的鉴别诊断效果,值得临床广泛应用.

Tumor markers in differential diagnosis of benign and malignant ovarian tumors

Objectives： To analyze the role tumor markers plays in the diagnosis of benign and malignant tumors and to provide the theory basis for the diagnosis of ovarian tumors. Method： 171 cases of OT inpatients ad- mitted into our hospital from September 2007 to March 2010 were selected and divided into two groups, the benign group （ n = 94） and the malignant group （ n = 77）. 80 healthy women were chosen as the control group. Differences in the level of tumor markers were compared among the subjects in the three groups. Results： The tumor marker levels of CA125, CA153, CA199, CA2d2, CEA and ferritin of the OT group were significantly higher than that of the control group; tumor marker levels of patients with the malignant tumor were significantly higher than those with benign tumor （P 〈 0. 05）. The levels of NSE,β - HCG, AFP, PSA, f - PSA and HCG showed no statistical difference in the three groups （P 〉 0. 05）. In the malignant group, the positive rate of CA125, CA153, CA199, CA242, CEA, ferritin,β - HCG, AFP and HGH was significantly higher than those in the benign group and control group, with significant statistical difference （P 〈 0. 05 ）. Conclusion： Tumor markers of CA125, CA199, CA242, CEA, ferritin, β - HCG, AFP and HGH play a useful role in the OT diagnosis of benign and malignant tumors. The higher level and positive rate of the tumor markers indicate more advanced OT development and higher risk of malignant tumors. The combined test of CA125, CA199 and CEA can obtain good detection effect with less cost, which is worthy of wide clinical application.