生殖器疱疹病毒感染对精液质量和细胞免疫功能的影响

目的：探讨生殖器疱疹病毒感染对男性患者精液质量和T细胞免疫功能的影响.方法：38例男性生殖器疱疹病毒感染患者为病例组,20例健康体检者为对照组,分析两组精液量、PH值、精子密度、精子存活率、精子活力和精子正常形态率等精液质量指标;采用流式细胞仪分析CD3＋、CD4＋和CD8＋T细胞百分率.结果：精液质量比较,病例组精液量、精液PH值、精液液化时间、精子密度和精子正常形态率与对照组均无明显差异（P〉0.05）,精子存活率[（47.58±13.36）%比（68.92±9.07）%]和精子活力[（45.46±14.11）%比（56.54±12.27）%]均显著降低（P〈0.01）;细胞免疫功能比较,病例组CD3＋ 及CD8＋T细胞百分率无统计学差异,但CD4＋T细胞百分率[（23.62±3.42）%比（33.16±3.75）%]与CD4＋/CD8＋[（0.83±0.12）比（1.45±0.27）]均显著降低（P〈0.01）.结论：男性生殖器疱疹病毒感染可导致精液质量下降和T细胞免疫功能低下.

Influence of genital herpes virus infection on the quality of semen and cellular immune function

Objectives： To explore the influence of genital herpes simplex virus infection in male patients on the quality of semen and T cell - mediated immune function. Method： 38 cases of male patients with genital herpes simplex virus infection were selected as the case group, and 20 healthy men were selected as the control group. The analyses of semen quality indexes of the 2 groups, including semen volume, sperm pH, sperm density, sperm viability, motility and normal sperm morphology rate were conducted. The percentage of CD3 ＋ , CIM ＋ and CD8 ＋ T cells were detected by flow cytometry. Results： The semen volume, sperm pH, semen liquefaction time, sperm density and sperm morphology rate had no significant difference between the 2 groups （ P 〉 0. 05 ）. In the case group, the sperm survival rate [（47.58 ± 13.36）% vs. （68.92 ±9.07）%] and sperm motility [（45.46 ± 14. 11 ） % vs. （56. 54 ± 12.27） % ] were significantly lower than those in the control group （ P 〈 0. 01 ）. There were no significant differences in CD3 ＋ and CD8 ＋ T cells percentage between the 2 groups, but the percentage of CIM ＋ T cells [ （23.62 ± 3.42） % vs. （33. 16± 3.75 ） % ] and CD4 ＋/CD8 ＋ [ （0. 83 ± 0. 12） vs. （ 1.45 ± 0. 27） ] in the case group were significant lower than those in the control group （ P 〈 0. 01 ）. Conclusion： Genital herpes virus infection in male patients can decrease the quality of semen and T cell - mediated immune function.