四环素治疗纳米细菌感染的Ⅲ型前列腺炎疗效观察

目的观察四环素治疗纳米细菌感染的Ⅲ型前列腺炎的临床效果。方法 86例纳米细菌感染的Ⅲ型前列腺炎患者分为观察组和对照组,每组43例。观察组患者给予四环素治疗,对照组患者给予左氧氟沙星治疗,连续用药1个月后,观察2组患者前列腺炎症状指数(NIH-CPSI)评分、前列腺液卵磷脂小体及纳米细菌再培养情况。结果治疗前2组患者NIH-CPSI、疼痛、排尿症状、生活质量及卵磷脂小体级别评分比较差异均无统计学意义(P>0.05)。观察组患者治疗后NIH-CPSI、疼痛、排尿症状及生活质量评分显著低于治疗前,卵磷脂小体级别评分显著高于治疗前,差异均有统计学意义(P<0.05)。对照组患者治疗前后NIH-CPSI、疼痛、排尿症状、生活质量及卵磷脂小体级别评分比较差异均无统计学意义(P>0.05)。治疗后观察组患者NIH-CPSI、疼痛、排尿症状及生活质量评分显著低于对照组,差异有统计学意义(P<0.01);治疗后观察组卵磷脂小体级别评分显著高于对照组,差异有统计学意义(P<0.05)。观察组和对照组患者治疗后前列腺液再培养后纳米细菌阳性例数分别为9例(20.9%)和43例(100.0%),观察组患者纳米细菌的阳性率显著低于对照组,差异有统计学意义(P<0.05)。结论四环素治疗纳米细菌感染的Ⅲ型前列腺炎效果显著,可作为治疗此类疾病的一线药物。

Effect of tetracycline on type HI prostatitis caused by nanobacteria

Objective To investigate the effect of tetracycline in treatment for type m prostatitis caused by nanobacte- ria. Methods A total of 86 patients with type III prostatitis caused by nanobacteria were divided into observation group and control group ,43 cases in each group. The patients in observation group were treated with tetracycline, and the patients in con- trol group were treated with levofloxacin for 1 month,then the national institutes of health-the prostatitis symptoms index（ NIH- CPSI） score,lecithin corpuscle and the cuhural result of nanobacteria in prostatic fluid were observed in the two groups. Re- suits There was no significant difference in the scores of NIH-CPSI, pain, emiction, life quality and lecithin corpuscle class between the two groups before treatment （P 〉 0.05 ）. The scores of NIH-CPSI, pain, emiction and life quality after treatment were significantly lower than those before treatment in observation group （ P 〈 0.05 ） , but the score of lecithin corpuscle class after treatment was significantly higher than that before treatment（P 〈 0.05 ）. There was no significant difference in the scores of NIH-CPSI,pain, emiction,life quality and lecithin corpuscle class before and after treatment in control group（ P 〉 0.05 ）. The scores of NIH-CPSI, pain, emiction and life quality in observation group were significantly lower than those in control group after treatment（ P 〈 0.01 ）. The score of lecithin corpuscle class in observation group was significantly higher than that in con- trol group after treatment （ P 〈 0.05 ）. The positive cases of nanobacteria in prostatic fluid in observation group and control group after treatment was 9 cases （20.9%） and 43 cases （ !00.0% ）, respectively ;the positive rate of nanobacteria in observa- tion group was significantly lower than that in control group （ P 〈 0.05 ）. Conclusions The effect of tetracycline for treating type Ill prostatitis caused by nanobacteria was significant. Tetracycline can be used as the first-line drug for type IlI prostatitis caused by nanobacteria.