| HPLC测定肝泰舒胶囊中獐牙菜苦苷含量 |
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| 引用本文： | 郭珊珊,曹文静,笔雪艳,张清波.HPLC测定肝泰舒胶囊中獐牙菜苦苷含量[J].中国中医药信息杂志,2014(1):69-71. |
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| 作者姓名： | 郭珊珊 曹文静 笔雪艳 张清波 |
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| 作者单位： | [1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江省食品药品检验检测所,黑龙江哈尔滨150001 |
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| 基金项目： | 2011年度国家药品标准提高研究（586） |
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| 摘 要： | 目的建立高效液相色谱方法测定肝泰舒胶囊中獐牙菜苦苷含量的方法。方法采用Waters Symmetry-C18色谱柱(4.6 mm×250 mm,5μm),以乙腈-0.02%磷酸为流动相进行梯度洗脱,流速为1.0 mL/min,检测波长为250 nm,柱温为室温。结果獐牙菜苦苷在0.373 556~2.988 448μg范围内呈良好的线性关系(r2=1.000 0),平均回收率为106.81%,RSD=3.7%。结论该方法快捷、准确、简便、重复性好,可用于肝泰舒胶囊的质量控制。
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| 关 键 词： | 肝泰舒胶囊 含量测定 獐牙菜苦苷 |
HPLC Determination of Swertiamarin in Gantaishu Capsules |
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| GUO Shan-shan,CAO Wen-jing,BI Xue-yan,ZHANG Qing-bo.HPLC Determination of Swertiamarin in Gantaishu Capsules[J].Chinese Journal of Information on Traditional Chinese Medicine,2014(1):69-71. |
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| Authors: | GUO Shan-shan CAO Wen-jing BI Xue-yan ZHANG Qing-bo |
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| Institution: | 1.Heilong]iang University of Chinese Medicine, Harbin 150040, China ; 2.Heilongliang Institute for Food and Drug Control, Harbin 150001, China) |
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| Abstract: | Objective To establish an HPLC method for determining the content of swertiamarin in Gantaishu capsules. Methods Using a Waters Symmetry C18 column （4.6 mm×250 mm, 5μm）, the mobile phase was acetonitrile-0.02%phosphoric acid, with flow rate of 1.0 mL/min. The detection wavelength was at 250 nm, the column temperature was room temperature. Results The content of swertiamarin showed a good linear relationship in the range of 0.373 556-2.988 448 μg, r 2=1.000 0. The average recovery was 106.81%, and RSD was 3.7%. Conclusion This method is fast, accurate and simple with good reproducibility, which can be applied to the quality control of Gantaishu capsules. |
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| Keywords: | Gantaishu capsules content determination swertiamarin |
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