小陷胸汤联合盐酸二甲双胍片治疗2型糖尿病痰湿蕴热型临床观察

目的观察小陷胸汤联合盐酸二甲双胍片对2型糖尿病(T2DM)痰湿蕴热型患者糖脂代谢的影响。方法 104例T2DM痰湿蕴热型患者按随机数字表法分为2组,每组52例。2组均行糖尿病生活方式干预。对照组用盐酸二甲双胍片0.5 g,每日2次口服;观察组在对照组基础上加用小陷胸汤,每日1剂,分3次温服。治疗12周。2组患者均于治疗前后检测空服血糖(FBG)、糖化血红蛋白(HbA1C)、餐后2 h血糖(2 hPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并进行疗效评定。结果临床疗效总有效率观察组为92.31%(48/52),对照组为76.92%(40/52),观察组优于对照组(P0.01)。症状积分及FBG、2hPG、TC、TG、HDL-C、LDL-C水平治疗前后及治疗后2组比较差异均有统计学意义(P0.05)。结论小陷胸汤与盐酸二甲双胍片合用能有效降低T2DM痰湿蕴热型患者血糖、血脂水平,可明显提高疗效,改善糖脂代谢。

Clinical Observation of Xiaoxianxiong Decoction Combined with Metformin in Treating Phlegm-heat Type 2 Diabetic Patients

Objective To observe the effect of Xiaoxianxiong Decoction combined with metformin on glucose and lipid metabolism of phlegm-heat type 2 diabetic patients （T2DM）. Methods Totally 104 phlegm-heat T2DM patients were randomly divided into two groups （each contains 52 cases）, and given the diabetes lifestyle intervention. Control group additionally took 0.5 g metformin twice daily. And treatment group, besides taking 0.5 g metformin, was given Xiaoxianxiong Decoction, one dose and three times per day warmly. After 12 weeks, FBG, HbA1C, TC, TG, HDL-C, LDL-C, 2 hPG of the two groups were determined, and the therapeutic effect was evaluated. Results The total effective rate in the treatment group was 92.31%, and 76.92% in control group （P〈0.01）. The difference in symptom score, FBG, 2hPG, TC, TG, HDL-C and LDL-C between the two group were significant, so as that between before and after treatment of both groups （P 〈0.05）. Conclusion Xiaoxianxiong Decoction combined with metformin can effectively lower the levels of blood glucose and blood lipid in phlegm-heat T2DM patients, enhance the therapeutic effect and improve the metabolism of glucose and lipid.