Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress |
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Authors: | Calmarza-Font Isabel Lagunas Natalia Garcia-Segura Luis M |
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Affiliation: | Instituto Cajal, CSIC, E-28002 Madrid, Spain |
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Abstract: | Estradiol has antidepressive and anxiolytic actions. However, its therapeutic use is limited by its peripheral effects. Selective estrogen receptor modulators may represent an alternative to estradiol for the treatment of depressive symptoms. Here we report that tamoxifen and raloxifene decrease immobility time in the forced swim test and increases the time spent in open arms in the elevated plus maze in ovariectomized mice submitted to chronic unpredictable stress. |
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Keywords: | Elevated plus maze Estradiol Forced swim test Raloxifene Tamoxifen |
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