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Coping in an intermittent swim stress paradigm compromises natural killer cell activity in rats |
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| Authors: | Eren Senem Drugan Robert C Hazi Agnes Flannery Graham Kent Stephen |
| Affiliation: | a School of Psychological Science, La Trobe University, Bundoora, VIC 3086, Australia b Department of Psychology, University of New Hampshire, Durham, NH 03824, USA c Immunogenetics Laboratory, Department of Genetics, La Trobe University, Bundoora, VIC, Australia |
| Abstract: | The effects of intermittent swim stress and stressor controllability on natural killer cell activity (NKCA) was examined. Significant decreases in splenic NKCA were observed immediately post-stress, but only when the stress was controllable. Although decreased NKCA was also observed in yoked rats subjected to the same stressor, it failed to attain statistical significance. Previous results suggest these effects are not due to corticosterone. The results suggest a cost of coping on the acute, in vitro immune measure of NKCA. |
| Keywords: | Stress Controllability Natural killer cell activity NKCA Corticosterone |
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