| 巨噬细胞移动抑制因子的信号转导研究进展 |
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| 引用本文： | 张韶辉,高东升. 巨噬细胞移动抑制因子的信号转导研究进展[J]. 国际病理科学与临床杂志, 2009, 29(1): 27-31 |
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| 作者姓名： | 张韶辉 高东升 |
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| 作者单位： | 天津医科大学,天津,300070;济宁医学院附属医院心内科,山东,济宁,272029 |
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| 摘 要： | 巨噬细胞移动抑制因子(MIF)是一种重要的多功能细胞因子,在机体中分布广泛,可能参与了机体多种病理生理反应,其信号转导机制复杂而广泛,主要有激活细胞外信号调节激酶1/2(ERK1/2)信号转导途径、NF-κB途径,Jab 1途径等;与众多自身免疫疾病密切相关。
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| 关 键 词： | 巨噬细胞移动抑制因子 信号转导 细胞外信号调节激酶1/2 |
| 收稿时间： | 2008-11-05 |
| 修稿时间： | 2008-12-07 |
Advances of signal transduction of macrophage migration inhibitory factor |
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| ZHANG Shaohui,GAO Dongsheng. Advances of signal transduction of macrophage migration inhibitory factor[J]. Journal of International Pathology and Clinical Medicine, 2009, 29(1): 27-31 |
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| Authors: | ZHANG Shaohui GAO Dongsheng |
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| Affiliation: | 1. Tianjin Medical University, Tianjin 300070; 2. Department of Cardiology, Affiliated Hospital of Jining Medical College, Jining Shandong 272029, China |
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| Abstract: | Macrophage migration inhibitory factor is a multipotent cytokine and be widely distributed in the body, it may be involved in a variety of physiological and pathological responses, its signal transduction mechanism is complex and extensive, such as extracelluclar-signal regulated kinase 1/2(ERK1/2) signal transduction pathway, NF-κB and Jab 1 signal transduction pathway.It is closely related to many complex autoimmune diseases, but the MIF signal transduction mechanisms were still not completely clarified. |
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| Keywords: | macrophage migration inhibitory factor signal transduction extracelluclar-signal regulated kinase 1/2 |
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