Twenty-four hour profiles of plasma C-peptide in Type 1 (insulin-dependent) diabetic children |
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Authors: | G A Werther R C Turner P A Jenkins J D Baum |
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Institution: | (1) Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, UK;(2) Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK;(3) Present address: Department of Endocrinology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, USA |
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Abstract: | Summary Twenty-four hour profiles of plasma C-peptide an index of endogenous insulin secretion, were performed in 15 Type 1 (insulin-dependent) diabetic children. Plasma C-peptide was detectable in six children, of whom four (C-peptide producers) had peak values above normal fasting levels. In each of the six children with residual B cell function, there was a close correlation between plasma C-peptide and simultaneous blood glucose (r> 0.50, p< 0.05). Post-breakfast peak blood glucose was 10.2 ± 1.7 mmol/l (mean ±SEM) in the C-peptide producers and 18.7 ± 1.7 mmol/l in the 11 children with low or no detectable C-peptide. Mean M-value, an index of deviation from an ideal blood glucose, was lower in the C-peptide producers (p<0.05). It is concluded that residual functioning B cells in diabetic children behave physiologically in that insulin secretion fluctuates in accordance with the prevailing blood glucose; and that the pattern of action of injected insulin is more critical in non-C-peptide producers who lack the post-prandial dampening effect provided by residual endogenous insulin secretion. |
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Keywords: | Type 1 diabetes diabetic children blood glucose profiles insulin C-peptide B cell |
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