| 白细胞介素2与狂犬疫苗联合免疫小鼠的抗体动态观察 |
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| 引用本文： | 刘劲松,伊纯德,刘慧,李燕,陆虹,宋绍勇,崔景辉,张守峰.白细胞介素2与狂犬疫苗联合免疫小鼠的抗体动态观察[J].临床军医杂志,1997(4). |
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| 作者姓名： | 刘劲松 伊纯德 刘慧 李燕 陆虹 宋绍勇 崔景辉 张守峰 |
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| 作者单位： | 大连市解放军大连医高专，北京市中国预防医学科学院病毒学研究所 |
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| 摘 要： | 组织培养制备的狂犬病毒灭活疫苗与重组白细胞介素２同时免疫ＢＡＬＢ／ｃ鼠和Ｓｗｉｓｓ鼠，检测不同时间的鼠血清中抗狂犬病毒ＩｇＧ抗体和中和抗体效价。结果显示，在白细胞介素２的作用下，抗体产生的时间提前，抗体效价提高（Ｐ＜０．０１），ＢＡＬＢ／ｃ鼠和Ｓｗｉｓｓ鼠比较，前者的抗体效价更高（Ｐ＜０．０１）。说明白细胞介素２可以提高小鼠的体液免疫反应。
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| 关 键 词： | 狂犬疫苗 白细胞介素2 中和抗体 |
Interleukin2 as an adjuvent to increase the antibodies level of inactivated rabies virus vaccine |
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| Abstract: | We were interested in determining whether the interleukin2 (IL 2) could be an adjuvent to increase the immune response of mouse to inactivated rabies virus vaccine.BALB/c mice and Swiss mice were divided equally into two groups respectively.They were immunized by the inactivated rabies virus vaccine with IL 2 or without IL 2.The results showed that the anti virus IgG antibodies and virus neutralizing antibodies had appeared 5 days earlier for the group with IL 2 than the one without IL 2.The antibody titer had raised much higher for the group with IL 2 than another one. |
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| Keywords: | ? inactivated rabies virus vaccine interleukin2 virus neutralizing antibody |
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