Human interleukin-1 alpha is chemotactic for normal human keratinocytes |
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| Authors: | D N Sauder F W Orr S Matic D Stetsko K P Parker R Chizzonite P L Kilian |
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| Affiliation: | Department of Medicine, McMaster University, Hamilton, Ontario, Canada. |
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| Abstract: | Interleukin-1 (IL-1) has been shown to have mitogenic and chemotactic properties for a variety of cell types includes keratinocytes. These studies suggested that keratinocytes possess receptors for IL-1. In this study, the chemotactic properties of IL-1 for keratinocytes were confirmed and IL-1 receptors were demonstrated on keratinocytes using a radio receptor assay. Crosslinking studies with IL-1 alpha identified two major bands of Mr 97 kDa and 133 kDa. Thus, keratinocytes possess high affinity IL-1 receptors and respond to IL-1 by directed migration. |
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