电针对侧脑室注入马桑内酯所致大鼠海马单位痫样放电的影响

<正> 电针对脑电图癫痫波有抑制作用。并证明电针抑制痫波与内啡肽、五-羟色胺、r-氨基丁酸有关。但是,电针对于单个神经元的癫痫样放电有何作用,电针不同穴位以及用不同参数电针穴位对于神经元痫样放电的影响有何差异?迄今为止还尚无

EFFECTS OF ELECTROACUPUNCTURE ON EPILEPTIFORM HIPPOCAMPAL UNIT ACTIVITY BY INTRACEREBROVENTRICULAR INJECTION OF CORIARIA LACTONE

In our present study we build up a new experimental model in the rat for epilepsy by intracerebroventricular injection of Coriaria Lactone (CL) and examine the effects of electroacupuncture on epileptiform hippocampal unit activity. Three types of hippocampal units responding to CL were observed:a) positive units b) negative units and c) indifferent units. The activity of positive units may be the typical epileptiform hippoeampal activity. The positive units can be inhibited by electroacupuncture (EA), weile the negative units can be exhilarated by EA. No changes were observed in indifferent units. Inhibitory effects of positive units are different because of using different "acupoints". EA of Du-Mo and Taichong Kunlun in the other side of drug injection were significatively better than Taichong Kunlun in the same side of drug injection. Effects of Du-Mo was significatively better than the effects of the points on the limb. Parameters of EA are significatively different in other side of limb points for inhibition of positive units:5V 1Hz, 5V 5Hz>1V 5Hz>1V 1Hz. These data indicate that effects of EA are depend on amplitude of EA, and seem not to be concern with frequencies of EA. The amplitude and frequency of hippocampal EEG spikes can be inhibited by EA. The inhibitory role of EA on epileptiform discharges is also discussed in this paper.