扶正消瘿汤联合左甲状腺素钠片治疗桥本甲状腺炎疗效及对血清炎症因子的影响

目的：观察扶正消瘿汤联合左甲状腺素钠片治疗桥本甲状腺炎（HT） 的疗效及对血清炎症因子的影响。方法：选取90例HT患者，按随机数字表法分为观察组及对照组各45例。对照组服用左甲状腺素钠片治疗，观察组在对照组基础上加用扶正消瘿汤。比较2组临床疗效及不良反应发生情况，比较2组治疗前后中医证候积分、甲状腺体积、实验室检查指标[白细胞介素-6（IL-6）、白细胞介素-12（IL-12）、肿瘤坏死因子-α（TNF-α）、游离三/四碘甲状腺原氨酸（FT3/FT4）、促甲状腺激素（TSH）、过氧化物酶抗体（TPOAb）、球蛋白抗体（TGAb） ]值的变化。结果：治疗后，2组中医证候积分均较治疗前下降（P＜0.05），观察组中医证候积分低于对照组（P＜0.05）。观察组临床疗效总有效率为93.33%，对照组临床总有效率为75.56%，2组临床疗效比较，差异有统计学意义（P＜0.05）。治疗后，2组甲状腺体积均较治疗前缩小（P＜0.05），观察组甲状腺体积小于对照组（P＜0.05）。治疗后，2 组IL-6、IL-12、TNF-α、TSH、TPOAb、TGAb 水平均较治疗前下降（P＜0.05）， FT3、FT4 水平均较治疗前上升（P＜0.05）； 观察组IL-6、IL-12、TNF-α、TSH、TPOAb、TGAb水平均低于对照组（P＜0.05），FT3、FT4水平均高于对照组（P＜0.05）。治疗期间，2组患者出现不良反应经休息后，均自行恢复。结论：扶正消瘿汤联合左甲状腺素钠片治疗HT能有效提高临床疗效，抑制血清炎症因子水平，降低炎症反应，缓解临床症状。

Curative Effect of Fuzheng Xiaoying Decoction Combined with Levothyroxine SodiumTablets for Hashimoto Thyroiditis and Its Effects on Serum Inflammatory Factors

Abstract： Objective： To observe the curative effect of the therapy of Fuzheng Xiaoying Decoctioncombined with Levothyroxine Sodium Tablets on hashimoto thyroiditis (HT) and its effects on seruminflammatory factors. Methods： A total of 90 HT patients were selected and divided into the observationgroup and the control group according to the random number table method，with 45 cases in each group.The control group was given Levothyroxine Sodium Tablets for treatment，and the observation group wasadditionally treated with Fuzheng Xiaoying Decoction based on the treatment of the control group. Theclinical effects and incidence of adverse reactions，and the changes in traditional Chinese medicine (TCM) syndrome scores，thyroid volume，and levels of laboratory parameters [interleukin-6 (IL-6)，interleukin- 12 (IL-12)， tumor necrosis factor- α (TNF- α)， free triiodothyronine 3/free triiodothyronine 4 (FT3/FT4)，thyroid stimulating hormone (TSH)， thyroid peroxidase antibody (TPOAb) and thyroglobulin antibodies(TGAb)] were compared before and after treatment between the two groups. Results：After treatment，theTCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). The total clinical effective rate was 93.33% in the observation group and 75.56% in the control group，the difference being significant (P＜0.05). After treatment， the thyroid volume in the two groups wasreduced when compared with that before treatment (P＜0.05)， and the thyroid volume in the observationgroup was less than that in the control group (P＜0.05). After treatment，the levels of IL-6，IL-12，TNF-α，TSH，TPOAb and TGAb in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of FT3 and FT4 were increased when compared with those before treatment (P＜0.05)；the levels of IL-6，IL-12，TNF- α，TSH，TPOAb and TGAb in the observation group were lowerthan those in the control group (P＜0.05)，and the levels of FT3 and FT4 were higher than those in the controlgroup (P＜0.05). During treatment，adverse reactions occurred in the two groups，and they recovered afterrest. Conclusion：The therapy of Fuzheng Xiaoying Decoction combined with Levothyroxine Sodium Tabletscan enhance the clinical effect on HT patients，which can inhibit the levels of serum inflammatory factors，reduce the inflammatory responses and mitigate the clinical symptoms.