他克莫司软膏联合米诺地尔酊治疗白癜风的效果

目的 观察他克莫司软膏联合米诺地尔酊在白癜风患者治疗中的应用效果。方法 选取2022年 5月-2023年5月我院收治的72例白癜风患者为研究对象，采用随机数字表法分为对照组和观察组，各组 36例。对照组采用米诺地尔酊治疗，观察组采用他克莫司软膏联合米诺地尔酊治疗，比较两组临床疗效、 不良反应发生情况、白斑面积及生活质量。结果 观察组治疗总有效率为94.44%，高于对照组的80.56%，差 异有统计学意义（P＜0.05）；观察组不良反应发生率为8.33%，低于对照组的11.11%，但差异无统计学意义 （P＞0.05）；两组治疗后白斑面积均小于治疗前，且观察组小于对照组，差异有统计学意义（P＜0.05）；两组 治疗后DLQI评分均低于治疗前，且观察组低于对照组，差异有统计学意义（P ＜0.05）。结论 他克莫司 软膏联合米诺地尔酊外涂治疗白癜风的效果理想，可提高治疗总有效率，减小白斑面积，改善患者的生活 质量，且不会增加不良反应发生风险，可作为一种可行、有效、安全的治疗方法加以应用。

Effect of Tacrolimus Ointment Combined with Minoxidil Tincture in the Treatment of Vitiligo

Objective To observe the application effect of tacrolimus ointment combined with minoxidil tincture in the treatment of vitiligo patients. Methods A total of 72 patients with vitiligo admitted to our hospital from May 2022 to May 2023 were selected as the research objects. They were divided into control group and observation group by random number table method, with 36 patients in each group. The control group was treated with minoxidil tincture, and the observation group was treated with tacrolimus ointment combined with minoxidil tincture. The clinical efficacy, adverse reactions, white spot area and quality of life were compared between the two groups. Results The total effective rate of treatment in the observation group was 94.44%, which was higher than 80.56% in the control group, and the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 8.33%, which was lower than 11.11% in the control group, but the difference was not statistically significant (P >0.05). After treatment, the white spot area of the two groups was smaller than that before treatment, and that of the observation group was smaller than that of the control group, the difference was statistically significant (P <0.05). The DLQI scores of the two groups after treatment were lower than those before treatment, and the observation group was lower than the control group, the difference was statistically significant (P <0.05). Conclusion Tacrolimus ointment combined with minoxidil tincture is effective in the treatment of vitiligo, which can improve the total effective rate of treatment, reduce the area of leukoplakia, improve the quality of life of patients, and will not increase the risk of adverse reactions. It can be applied as a feasible, effective and safe treatment method.