棱莪消积汤联合抗生素治疗慢性盆腔炎疗效及对炎性因子、复发率的影响

目的：观察棱莪消积汤联合抗生素治疗慢性盆腔炎的疗效及对炎性因子、复发率的影响。方法：选取110例慢性盆腔炎患者，按随机数字表法分为治疗组与对照组各55例。对照组给予常规抗生素治疗，治疗组在对照组基础上联合棱莪消积汤治疗。比较2组临床疗效及不良反应发生率、复发率，比较2组治疗前后湿热瘀结型中医证候积分、炎性因子[白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C-反应蛋白（CRP） ]水平的变化。结果：治疗后，治疗组总有效率为96.36%，对照组为83.64%，2 组比较，差异有统计学意义（P＜0.05）。治疗后，2 组下腹部胀痛、带下量多、色黄质稠、月经异常湿热瘀结型评分均较治疗前下降（P＜0.05），治疗组上述4项评分均低于对照组（P＜0.05）。治疗后，2组TNF-α、CRP水平均较治疗前下降（P＜0.05），IL-6 水平均较治疗前上升（P＜0.05）；治疗组IL-6 水平高于对照组（P＜0.05），TNF-α、CRP水平均低于对照组（P＜0.05）。对照组不良反应发生率为21.82%，治疗组为5.46%，2组不良反应发生率比较，差异有统计学意义（P＜0.05）。对照组复发率为17.39%，治疗组复发率1.89%，2组复发率比较，差异有统计学意义（P＜0.05）。结论：棱莪消积汤联合抗生素治疗慢性盆腔炎可改善临床症状，降低炎症反应，降低疾病复发率，用药安全性高。

Effect of Leng''e Xiaoji Decoction Combined with Antibiotics on Chronic PelvicInflammatory Disease and Its Influence on Inflammatory Factors and RecurrenceRate

Abstract： Objective： To observe the effect of Leng''e Xiaoji Decoction combined with antibiotics onchronic pelvic inflammatory disease and its influence on inflammatory factors and recurrence rate. Methods：A total of 110 patients with chronic pelvic inflammatory disease were selected and divided into thetreatment group and the control group according to the random number table method， with 55 cases ineach group. The control group was conventionally given antibiotics， and the treatment group wasadditionally treated with Leng''e Xiaoji Decoction based on the treatment of the control group. The clinicaleffects，incidence of adverse reactions，recurrence rates in the two groups were compared. The changesof traditional Chinese medicine syndrome scores of binding of damp-heat stasis type and inflammatoryfactors [interleukin-6 (IL-6)，tumor necrosis factor-α (TNF-α)，C-reactive protein (CRP)] were comparedbefore and after treatment between the two groups. Results：After treatment，the total effective rate was96.36% in the treatment group， and 83.64% in the control group， the difference being significant (P＜0.05). After treatment，the scores of lower abdominal distension，abnormal amount of vaginal discharge，thick and yellow vaginal discharge，abnormal menstruation of binding of damp-heat stasis type in the twogroups were decreased when compared with those before treatment (P＜0.05)，and the above four scoresin the treatment group were lower than those in the control group (P＜0.05). After treatment，the levels ofTNF-α and CRP in the two groups were decreased when compared with those before treatment (P＜0.05)，and the IL-6 levels were increased when compared with those before treatment (P＜0.05)；the IL-6 levelin the treatment group was higher than that in the control group (P＜0.05)，and the TNF-α and CRP levelswere lower than those in the control group (P＜0.05). The incidence of adverse reactions in the control groupwas 21.82%，and 5.46% in the treatment group，the difference being significant (P＜0.05). The recurrencerate in the control group was 17.39%，and 1.89% in the treatment group，the difference being significant(P＜0.05). Conclusion： The therapy of Leng''e Xiaoji Decoction combined with antibiotics can improveclinical symptoms， reduce inflammatory response， and reduce the recurrence rate of the disease， withgreat safety.