新型冠状病毒相关眼部疾病的研究进展

2019年新型冠状病毒肺炎(COVID-19)自爆发以来已在短时间内呈现出全球大流行状态，新型冠状病毒(SARS-CoV-2)的多种变异株具有高度传染性和致病性。SARS-CoV-2可能通过血管紧张素转化酶2(ACE2)和跨膜丝氨酸蛋白酶2(TMPRSS2)的介导感染组织细胞从而引发不同疾病。呼吸道、心血管、胃肠道系统的临床疾病较为常见； 也有大部分患者以眼部症状为主诉就诊。相较于严重的全身系统疾病，眼部相关症状很容易被忽视。文章通过对SARS-CoV-2相关多种眼部疾病的发病机制和相关病例进行综述，旨在增强临床医师对SARS-CoV-2相关眼病的重视，避免延误病情，造成视力的不可逆损失，并为眼部疾病的预防和治疗提供新思路。

Research progress on ocular diseases associated with SARS-CoV-2

The corona virus disease 2019(COVID-19)in 2019 has shown a global pandemic status in a short time since its outbreak, and many variants of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)were highly infectious and pathogenic. SARS-CoV-2 may infect tissue cells through the mediation of angiotensin-converting enzyme-2(ACE2)and transmembrane serine protease 2(TMPRSS2), leading to different diseases. Clinically, respiratory, cardiovascular, and gastrointestinal systems diseases are relatively common; many patients also seek medical attention based on eye symptoms as their main complaint. Compared with severe systemic diseases, eye-related symptoms are easily overlooked. This article reviews the pathogenesis and cases of various eye diseases related to SARS-CoV-2, aiming to enhance clinicians'' attention to SARS-CoV-2-related eye diseases, avoid delaying the disease and causing irreversible loss of vision, and provide new ideas for the prevention and treatment of eye diseases.